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Genmab — Januar 2017

Planlagt Fastgjort Låst Flyttet Genmab
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  • M Offline
    M Offline
    mobbyduck1
    wrote on sidst redigeret af
    #861

    60-70 mio herfra, andre der er meget højere, men det er nok ret realistisk

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    • B Offline
      B Offline
      bibob
      wrote on sidst redigeret af
      #862

      Tror du rammer intervallet meget godt mobbyduck. Alt derover vil være fremragende:-)

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      • BulderB Offline
        BulderB Offline
        Bulder
        wrote on sidst redigeret af
        #863

        Fik først nu øje på jkj's link til FW-pharma. De kommercielle forventninger til Darzalex er øget substantielt ud over de 9 mia peaksale i MM. Det bliver sværere og sværere at bevare pessimismen.

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        • B Offline
          B Offline
          bibob
          wrote on sidst redigeret af
          #864

          Celgene strikes possible takeover deal for in- demand Anokion

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          • B Offline
            B Offline
            bibob
            wrote on sidst redigeret af
            #865

            Immatics bags $ 1 B tie- up With Amgen for cancer immune therapies

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            • B Offline
              B Offline
              bibob
              wrote on sidst redigeret af
              #866

              Begge nyheder idag på Fierce Biotek. ( kan desværre ikke linke )

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              • G Offline
                G Offline
                GeorgeBest
                wrote on sidst redigeret af
                #867

                Access denied | www.fiercebiotech.com used Cloudflare to restrict access | www.fiercebiotech.com | Cloudflare

                favicon

                (www.fiercebiotech.com)

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                • G Offline
                  G Offline
                  GeorgeBest
                  wrote on sidst redigeret af
                  #868

                  Access denied | www.fiercebiotech.com used Cloudflare to restrict access | www.fiercebiotech.com | Cloudflare

                  favicon

                  (www.fiercebiotech.com)

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                  • G Offline
                    G Offline
                    gentogen
                    wrote on sidst redigeret af
                    #869

                    the HDACi Panobinostat induces upregulation of CD38 on myeloma and a subsequent dramatic increase of Daratumumab-mediated ADCC in pre-clinical models. Fra Blood 2016 128:4481. Panobinostat er Novartis (Farydak)

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                    • G Offline
                      G Offline
                      gentogen
                      wrote on sidst redigeret af
                      #870

                      Panobinostat could be used synergistically with Daratumumab in a clinical setting to increase response rates and extend duration of responses

                      1 Reply Last reply
                      0
                      • B Offline
                        B Offline
                        bibob
                        wrote on sidst redigeret af
                        #871

                        Tak GB 😉

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                        • BulderB Offline
                          BulderB Offline
                          Bulder
                          wrote on sidst redigeret af
                          #872

                          Kan du vurdere, gentogen, om det er mere effektivt end ATRA til opregulering af CD38? Ved du om der er studier på vej dara+pano?

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                          • S Offline
                            S Offline
                            Sun
                            wrote on sidst redigeret af
                            #873

                            Det er lige en kommentar til snakken igår omkring Darzalex og solide tumorer. @ Fantomas: Ang behandling af solide tumorer med antistoffer, så er dette allerede en succes ved brystkræft. Så det kan ikke passe at antistofferne ikke kan bruges til behandling af solide tumorer. Solide tumorer skal også have næring via blodet, og får cancercellerne ikke næring dør de. Så kommer der antistoffer i blodet, leveres de også til cancercellerne.

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                            • G Offline
                              G Offline
                              gentogen
                              wrote on sidst redigeret af
                              #874

                              Ved ikke mere Bulder, men "a large Phase III trial of panobinostat, a new type of myeloma drug called a HDAC inhibitor, were reported. Panobinostat is likely to be the next new agent to be approved by the FDA for relapsed/refractory multiple myeloma. This study evaluated panobinostat in combination with Velcade-dex and showed significantly improved outcomes as compared to Velcade-dex alone". http://multiplemyelomablog.com/2014/06/asco-news-panobinostat-sar650984-and-daratumumab.html

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                              • G Offline
                                G Offline
                                gentogen
                                wrote on sidst redigeret af
                                #875

                                Altså en gammel nyhed fra ASCO 14

                                1 Reply Last reply
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                                • BulderB Offline
                                  BulderB Offline
                                  Bulder
                                  wrote on sidst redigeret af
                                  #876

                                  ja, i mellemtiden er pano blevet godkendt. Så nu har vi 3 stoffer der potentielt kan hjælpe mod dara-resistens: ATRA, Sepantronium bromide (YM155) og nu Panobonistat.

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                                  • BulderB Offline
                                    BulderB Offline
                                    Bulder
                                    wrote on sidst redigeret af
                                    #877

                                    Panobino...

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                                    0
                                    • S Offline
                                      S Offline
                                      Sukkeralf
                                      wrote on sidst redigeret af
                                      #878

                                      Og da panobino stat tillige har andre virkningsmekanismer, så kunne det være sjovt at se den.

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                                      • BulderB Offline
                                        BulderB Offline
                                        Bulder
                                        wrote on sidst redigeret af
                                        #879

                                        Nemlig

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                                        • Legolas23L Offline
                                          Legolas23L Offline
                                          Legolas23
                                          wrote on sidst redigeret af
                                          #880

                                          Hvad kan stoffet og hvad tilfører det siden det virker bedre en Vel-dax alene..

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                                          0

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