Genmab — Maj 2016
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Nu har jeg haft tid til at læse Novods Genmab note fra i morges igen. En har specielt fremhæver er "very importantly, als can be seen from the PFS Kaplan Mayer curve below, we also see that after 15 months, the Darzalex/Rev/Dex curve completely flattens, i.e. patients to not progress, which is a very promissing sign in our view and could indicate the immonu-oncology properties of Darzalex."
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Jeg kan ikke vise kurven, men jeg tror teksten siger alt. Empliciti/Rev/Dex kurven fortsætter bare i hullet!
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I forhold til Darzalex/Rev/Dex.
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Begge bliver målt mod Rev/Dex. Men Darzalex/Rev/Dex da flader kurven totalt efter 15 måneder. Dvs sygdommen udvikler sig ikke yderligere i negativ retning. Det gør den fortsat i Empliciti armen med Rev/Dex.
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Darzalex/Rev/Dex kurven stopper efter 21 måneder (ikke mere data). Dvs fra 15. til 21. måned udvikler sygdommen sig ikke yderligere negativt
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Pollux nu omtalt på Myeloma Beacon. Dog kun pressemeddelelsen - ikke abstractet pga embargo. http://www.myelomabeacon.com/news/2016/05/20/myeloma-morning-important-transplantation-and-darzalex-trial-results/
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Elotuzumab+Rd-kurven kan ses i fig 1 i dette dkument: http://www.nejm.org/doi/full/10.1056/NEJMoa1505654?af=R&rss=currentIssue#t=articleResults Dara+Rd-kurven kan ses her nederst i EHA-abstractet: http://learningcenter.ehaweb.org/eha/2016/21st/135349/meletios.a.dimopoulos.an.open-label.randomised.phase.3.study.of.daratumumab.html?f=p16m3l9759
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Og først efter 31 måneder!
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