Genmab — April 2014
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det jeg også glæder mig til at se til ASCO er om dara reelt virker bedre i 8 + 16 mg. det første monostudiet samt de foreløbige data i kombostudiet var jo lidt blandet hvor det reelt indtil videre er 4 mg der virker bedst
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derfor håber jeg meget at se nogle stærke solide responser i 8 og især 16 mg. så vi kan få bekræftet at det er den bedste og rigtige dosis. især fordi det kan tyde på at Sanofi gerne vil holde 10 mg. (de har dog åbnet for 20 så vidt jeg kan se)
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The 17 MM patients were older and heavily pretreated patients; median age of 64 years (range: 55-74); and median of seven prior regimens (range: 2-14). All MM patients had received prior lenalidomide and bortezomib. The median time from diagnosis to first SAR650984 dosing was 6. 8 years (range 1.8 16.8 years). Responses in this group (fig 1), according to EBMT MM criteria, included 1 PR at 1 mg/kg (n = 3) and 5 mg/kg (n=3), and 1 MR at DL 3 mg/kg (n = 6). The 10 mg/kg DL demonstrated 3 PR and 2
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Vi kommer til at se CR i 16mg, det vil jeg godt sætte en ti'er på.
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madsSkjern det er jeg også sikker på. det jeg selv håber er at når 2/3 patienter i 4 mg. allerede har fået CR at vi har gode muligheder for minimum at holde 66% i de høje dosis og måske endda øge dette
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Det her er til gengæld rigtig flot af SAR: Among the 8 patients with objective responses (CR, PR or MR), 6 were still on treatment at the time of data cutoff for presentation. Four of these patients had been on treatment for more than 26 weeks, and one had been on for over one year
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BTW er jeg den eneste der pt. kan tælle langt over 100 sites i Dara+revlimid studiet ?
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det blev opdateret 17/4 dvs. i torsdags hvor der kom 25-30 flere sites på så der nu er et godt stykke over 100 sites klar til at indrulle de 500 patienter !
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men når man bruere strengere inkluteringsvilkår får man vel også bedre resultater end hvis man er mere løssluppen ifht. de patienter man vil have ind ?
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arh okay så forstår jeg bedre
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