Genmab — November 2013

[JKY_VH]

Tak gentogen.

[JørgenVarnæs]

Det er en forbavsende styrke GEN viser i dag. Mon vi har vendt faldet ryggen og går ind i en ny fase nu?

[Solsen]

Tror vi skal en eller to uger frem før der købes op mhb på gode ash nyheder. Inden da kan en test af 200 sagtens ske.

[gentogen]

Complement Activations through IgG Hexamers
Complement activation by antibodies represents a potent form of immune defense. By using cryo-electron tomography and mutagenesis studies we reveal the molecular mechanism by which antibody complexed to antigen triggers complement activation. Our data provide a model for understanding complement activation by antibodies and provides leads for its modulation.
Janine Schuurman, Ph.D., Director, Strategic Research, Genmab B.V., The Netherlands

[gentogen]

Muligvis gammelt nyt. Der er så meget pt...http://www.ibclifesciences.com/AntibodyEng/agenda.xml

[investor1989]

Carnegie har en rigtig god pointe omkring Genmab. med over 30+% af patienter med Gazyva der har grade 3´+ infusion eller neutropenia events vil en meget stor del af de patienter nok stoppe med Gazyva og gå Arzerra eller Rituxan

[investor1989]

Så selv hvis Gazyva bliver lægernes første valg, vil en stor af patienterne nok indse at de ikke kan tåle Gazyva og skifte behandling ?

[gentogen]

I patienter uden NOTCH1 mutation er PFS 23,3 for OC kombinationen https://ash.confex.com/ash/2013/webprogram/Paper58266.html

[gentogen]

I øvrigt er jeg helt enig i det foregående. Og hvis Gazyva vælges fra, så er Arzerra nærliggende, da det jo ser ud til at være bedre end Ritux på alle parametre

[Solsen]

19% gennemførte ikke behandlingsforløbet med Gazyva. Altså hver femte pts måtte afbryde ! (Lige som jeg husker)

[Solsen]

Første behandling over to dage og groft sagt livsfarligt !

[gentogen]

Ja. The first dose of GAZYVA was divided between day 1 (100 mg) and day 2 (900 mg) [see Dosage and Administration (2.1)], which was implemented in 45 patients.

[gentogen]

PML has been reported with GAZYVA

[gentogen]

Fatal cardiac events have been reported in patients treated with GAZYVA

[gentogen]

Hepatitis B virus reactivation has been reported with GAZYVA

[gentogen]

http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/125486s000lbl.pdf

[gentogen]

Den sidste er dog ikke kun for G, men alligevel...

[gentogen]

Roche: At the data cut-off, 9%, 15%, and 20% of the patients in the GClb, RClb, and Clb arms, respectively, had died.

[gentogen]

Ofatumumab: Deaths during treatment occurred in 2% of subjects in both arms

[Solsen]

Kapitalforhøjelse i Genmab