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Genmab — November 2013

Planlagt Fastgjort Låst Flyttet Genmab
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Denne tråd er blevet slettet. Kun brugere med emne behandlings privilegier kan se den.
  • G Offline
    G Offline
    gentogen
    wrote on sidst redigeret af
    #95

    Complement Activations through IgG Hexamers
    Complement activation by antibodies represents a potent form of immune defense. By using cryo-electron tomography and mutagenesis studies we reveal the molecular mechanism by which antibody complexed to antigen triggers complement activation. Our data provide a model for understanding complement activation by antibodies and provides leads for its modulation.
    Janine Schuurman, Ph.D., Director, Strategic Research, Genmab B.V., The Netherlands

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    • G Offline
      G Offline
      gentogen
      wrote on sidst redigeret af
      #96

      Muligvis gammelt nyt. Der er så meget pt...http://www.ibclifesciences.com/AntibodyEng/agenda.xml

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      • investor1989I Offline
        investor1989I Offline
        investor1989
        wrote on sidst redigeret af
        #97

        Carnegie har en rigtig god pointe omkring Genmab. med over 30+% af patienter med Gazyva der har grade 3´+ infusion eller neutropenia events vil en meget stor del af de patienter nok stoppe med Gazyva og gå Arzerra eller Rituxan

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        • investor1989I Offline
          investor1989I Offline
          investor1989
          wrote on sidst redigeret af
          #98

          Så selv hvis Gazyva bliver lægernes første valg, vil en stor af patienterne nok indse at de ikke kan tåle Gazyva og skifte behandling ?

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          • G Offline
            G Offline
            gentogen
            wrote on sidst redigeret af
            #99

            I patienter uden NOTCH1 mutation er PFS 23,3 for OC kombinationen https://ash.confex.com/ash/2013/webprogram/Paper58266.html

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            • G Offline
              G Offline
              gentogen
              wrote on sidst redigeret af
              #100

              I øvrigt er jeg helt enig i det foregående. Og hvis Gazyva vælges fra, så er Arzerra nærliggende, da det jo ser ud til at være bedre end Ritux på alle parametre

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              • SolsenS Offline
                SolsenS Offline
                Solsen
                wrote on sidst redigeret af
                #101

                19% gennemførte ikke behandlingsforløbet med Gazyva. Altså hver femte pts måtte afbryde ! (Lige som jeg husker)

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                • SolsenS Offline
                  SolsenS Offline
                  Solsen
                  wrote on sidst redigeret af
                  #102

                  Første behandling over to dage og groft sagt livsfarligt !

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                  • G Offline
                    G Offline
                    gentogen
                    wrote on sidst redigeret af
                    #103

                    Ja. The first dose of GAZYVA was divided between day 1 (100 mg) and day 2 (900 mg) [see Dosage and Administration (2.1)], which was implemented in 45 patients.

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                    • G Offline
                      G Offline
                      gentogen
                      wrote on sidst redigeret af
                      #104

                      PML has been reported with GAZYVA

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                      • G Offline
                        G Offline
                        gentogen
                        wrote on sidst redigeret af
                        #105

                        Fatal cardiac events have been reported in patients treated with GAZYVA

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                        • G Offline
                          G Offline
                          gentogen
                          wrote on sidst redigeret af
                          #106

                          Hepatitis B virus reactivation has been reported with GAZYVA

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                          • G Offline
                            G Offline
                            gentogen
                            wrote on sidst redigeret af
                            #107

                            http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/125486s000lbl.pdf

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                            • G Offline
                              G Offline
                              gentogen
                              wrote on sidst redigeret af
                              #108

                              Den sidste er dog ikke kun for G, men alligevel...

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                              • G Offline
                                G Offline
                                gentogen
                                wrote on sidst redigeret af
                                #109

                                Roche: At the data cut-off, 9%, 15%, and 20% of the patients in the GClb, RClb, and Clb arms, respectively, had died.

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                                • G Offline
                                  G Offline
                                  gentogen
                                  wrote on sidst redigeret af
                                  #110

                                  Ofatumumab: Deaths during treatment occurred in 2% of subjects in both arms

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                                  • SolsenS Offline
                                    SolsenS Offline
                                    Solsen
                                    wrote on sidst redigeret af
                                    #111

                                    Kapitalforhøjelse i Genmab

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                                    • SolsenS Offline
                                      SolsenS Offline
                                      Solsen
                                      wrote on sidst redigeret af
                                      #112

                                      Over 500K med 350K i niveauet 173-184kr. Pænt at tegne så tæt på aktuel kurs

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                                      • SolsenS Offline
                                        SolsenS Offline
                                        Solsen
                                        wrote on sidst redigeret af
                                        #113

                                        Hvis Winkel tegner heroppe er det vildt

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                                        • SolsenS Offline
                                          SolsenS Offline
                                          Solsen
                                          wrote on sidst redigeret af
                                          #114

                                          81 mio kr i provenu...

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