NOVO — Marts 2024
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Wegovy
approved in the US for cardiovascular risk reduction in people with overweight or obesity and established cardiovascular disease https://www.proinvestor.com/boards/119263 -
Novo Nordisk CEO says experimental weight loss pill could become a best-in-class drug https://www.cnbc.com/2024/03/08/novo-nordisk-ceo-weight-loss-pill-could-become-a-best-in-class-drug.html
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Jeg tror, at dette er det orale fase 1 amycretin forsøg på clinical trials. https://clinicaltrials.gov/study/NCT06049329?term=amycretin&rank=1&tab=table
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Det primære endemål i fase 1 forsøget med Amycretin var “Number of treatment emergent adverse events (TEAE)”. https://clinicaltrials.gov/study/NCT06049329?intr=Amycretin&rank=1
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De sekundære endemål var: AUC,MD; the area under the NNC0487-0111 plasma concentration-time curve after last multile dose, Cmax,MD; the maximum plasma concentration of NNC0487-0111 after last multiple dose, tmax,MD; the time of maximum plasma concentration of NNC0487-0111 after last multiple dose.
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Pharma Stock Roundup: NVO's New Obesity Pill Data, RHHBY, AZN's Pipeline Updates https://www.proinvestor.com/investornyt/1129459/pharma-stock-roundup-nvos-new-obesity-pill-data-rhhby-azns-pipeline-updates
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Amycretin Data er fra dette studie https://clinicaltrials.gov/study/NCT05369390?term=Obesity&lead=Novo Nordisk A%2FS&studyComp=2024-01-01_2024-03-01&rank=1
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6 forskellige doser fra 3mg op til 100mg
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Dertil testede de 2 forskellige formuleringer. Kaldet A og B i protokollen
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Jeg notere mig også udviklingschefen i går sagde at den kæmpe faktor 41x på api til henholdsvis wegovy og Rybelsus. At med Amycreatin forventer de at der forholdsmæssigt ikke bliver så stor forskel på oral og injektions variant af Amycretin
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Fase 1 injektions forsøget nævner ikke hvilke specifikke doser der testes
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Novos Martin Holst Lange om Amycretin https://www.reuters.com/business/healthcare-pharmaceuticals/novo-nordisk-hopes-launch-experimental-obesity-drug-within-this-decade-2024-03-08/
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Jeg er enig BB+. Det er en af de arme. Og alt andet lige enten 50mg eller 100mg dosering som de viste data for
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