Bavarian Nordic — Marts 2023
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Den 23/8 2021 meddelte BN, at de igangsatte fase 2 forsøget med covid-vaccinen med 150 sunde mennesker, der havde erhvervet immunitet enten via covid smitte eller gennem vaccinatione med eksisterende vacciner. Her ville BN's vaccine skulle vise effekten af et boost af SARS-CoV-2 antibody i kroppen. Desuden fik 60 mennesker, de rikke tidligere havde været syge af covid 2 injektioner med vaccinen for at vurdere effekten af vaccinens evne til at booste immunforsvaret.
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...harmonerer fint med min åbning på tråden, men så læste jeg lige, at primary completion date, definerers som 'The date on which the last participant in a clinical study was examined or received an intervention to collect final data for the primary outcome measure.'
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så lidt forvirring der...
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Biden administration warns of $35 billion shortfall for health emergency stockpile https://www.cbsnews.com/news/biden-administration-warns-of-35-billion-shortfall-for-health-emergency-stockpile/
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"This year, the Biden administration hopes Congress can enshrine pandemic preparedness needs as mandatory funding, akin to military defense spending. Department officials have previously warned about challenges restocking supplies depleted for the mpox response, which used drugs and vaccines initially saved up for a potential smallpox attack."
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Godmorgen
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Interview med Expres2ions CEO i dag i biostock.se: “Along the way, ExpreS2ion has seen positive phase II data, and the next important milestone will be a top-line readout from the ongoing phase III study. This is expected sometime in mid-2023” https://www.biostock.se/en/2023/03/expres2ions-ceo-on-current-development-and-the-rights-issue/
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Jeg tror desværre, at vi må vente et par måneder før der kommer store nyheder angående Covid Fase III. De er ikke klar med data før juni tidligst. Medmindre at der kommer en stor ordre på Mpox eller partneraftale angående RSV...
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Fra samme interview: – ABNCoV2 has a very competitive Covid-19 vaccine profile for several reasons. First of all, it has shown broad protection across variants of concern. So, while the virus continues to mutate, ABNCoV2 has continued to demonstrate protection. Secondly, it has shown a durability in protection – up to six months, which is very high in this field. Protection from the leading mRNA vaccines starts to wane at 3 – 4 months, requiring numerous booster injections. Let’s see if ...
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Nordic can also prove durability at 12 months very soon. Third, ABNCoV2 is based on a very stable protein construct that can be stored at refrigerator temperature and handled easily at room temperature – this is very promising for the supply-chain distribution of this vaccine in subtropical and tropical regions. Fourth, ABNCoV2 constitutes the only protein-based vaccine that does not need an adjuvant, which is indeed a very competitive advantage. Adjuvants are normal ingredients in most ....
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vaccines, primarily to serve as a modulator for an immune response, but even these particles may have a side effect and complicates clinical investigations. Avoiding adjuvants is a benefit that can strongly position ABNCoV2 as a safe and simple, yet effective, Covid-19 vaccine.
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