Genmab — December 2025
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RAINFOL-01 / Rina-S enlarged by ~200 patients, adding a few cohorts. a bit confusing, part H and J seem the same. maybe a different dosing schedule. They forgot the criteria for H. Interestingly cervical cancer is added.
https://clinicaltrials.gov/study/NCT05579366?tab=history&a=30&b=31&compareMode=sideBySide#version-content-panel -
Genmab Announces Data From Multiple Clinical Trials Showing Treatment with Fixed-Duration Epcoritamab Led to Remissions in First-Line Diffuse Large B-Cell Lymphoma (DLBCL) and Follicular Lymphoma (FL) https://ir.genmab.com/news-releases/news-release-details/genmab-announces-data-multiple-clinical-trials-showing-treatment
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Results from two arms of the EPCORE
NHL-2 trial, evaluating first-line, fixed-treatment duration epcoritamab in combination with chemotherapies, demonstrated overall response rates (ORR) of 93% (Arm 
and 98% (Arm 1) in patients with newly-diagnosed DLBCL, while a third arm (Arm 3) demonstrated a three-year overall survival (OS) rate of 96% in patients with FL following first-line combination treatment. -
Det er data som viser generelt høje responsrater, dybe og langvarige remissioner samt en håndterbar sikkerhedsprofil, især i udfordrende patientgrupper som ældre eller højrisikopatienter. Umiddelbart ser det ud til at epcoritamab på de fleste parametre giver baghjul til glofitamab og mosunetuzumab. Patientvenligheden med subkutan fixed-duration er et yderligere plus.
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Godmorgen
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https://www.onclive.com/view/epcoritamab-plus-r-mini-chop-may-aid-in-treatment-of-elderly-patients-with-first-line-dlbcl Epcoritamab Plus R-mini-CHOP May Aid in Treatment of Elderly Patients with First-Line DLBCL
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Raul Cordoba, MD, PhD #EHA2026 (@DrRaulCordoba) on X
Chea. Epcoritamab + R-miniCHOP in elderly 1L DLBCL. Very old population. But age was the main reason for not giving full dose of anthracycline in 97%. Lacking of frailty evaluation with geriatric assessment. #ASH25 #hematology #lymsm #geriheme https://t.co/D7yGlhWEm1
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