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  4. Genmab — Februar 2024

Genmab — Februar 2024

Planlagt Fastgjort Låst Flyttet Genmab
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  • SolsenS Offline
    SolsenS Offline
    Solsen
    wrote on sidst redigeret af
    #107

    Du skal ikke være ked af det Raun. Det er jo ikke et personligt angreb.

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    • S Offline
      S Offline
      Sukkeralf
      wrote on sidst redigeret af
      #108

      Håber at de får en stor spiller, hvis de har endnu et guldkorn i pipelinen. Synes stadig ikke de har erfaring nok til at løfte et kæmpe klinisk projekt alene eller sammen med BioNTech.

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      • JørgenVarnæsJ Offline
        JørgenVarnæsJ Offline
        JørgenVarnæs
        wrote on sidst redigeret af
        #109

        tilsammen har de 2 en krigskasse, der kan løfte lidt af hvert. Ikke siden zalutumumab har GEN lagt "dollars to donuts" - og jeg har savnet vilje til udvikling fra GENs side

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        • SolsenS Offline
          SolsenS Offline
          Solsen
          wrote on sidst redigeret af
          #110

          Vi er nok alle irriteret over kursen ikke er over 3000. Aktiekursen har sit eget liv, som JW siger. Vi kan ikke pege på en præcis årsag til at kursen roder rundt hernede. I min optik er kursen for lav. Men hvornår det bliver bedre vil jeg ikke gætte på.

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          • SolsenS Offline
            SolsenS Offline
            Solsen
            wrote on sidst redigeret af
            #111

            Vilje til udvikling ? Kig på R&D omkostningerne.

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            • JørgenVarnæsJ Offline
              JørgenVarnæsJ Offline
              JørgenVarnæs
              wrote on sidst redigeret af
              #112

              Masser af R, begrænset D og tungetunge administrationsomkostninger

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              • JørgenVarnæsJ Offline
                JørgenVarnæsJ Offline
                JørgenVarnæs
                wrote on sidst redigeret af
                #113

                var det ikke Novod, der kaldte set-uppet for "døde penge"

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                • E Offline
                  E Offline
                  E_L
                  wrote on sidst redigeret af
                  #114

                  the 50/50 split Genmab wants is a significant hurdle for partnerships with big pharma i believe. and very possibly one of the reasons some of the larger bi-specific deals we have seen over the last few months were not with genmab technology. But i can't blame them for pursuing 50/50, after what happened with JNJ, i would also not want to be in a position like that again...

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                  • JørgenVarnæsJ Offline
                    JørgenVarnæsJ Offline
                    JørgenVarnæs
                    wrote on sidst redigeret af
                    #115

                    But it's really not that hard - once you have run the safety/dose escalation part of the clinical development, you are in a very different place negotiation-wise. GEN has done very little of this. In fact, it seems they need to partner with other companies to have the necessary tech to even get programs into the clinic

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                    • S Offline
                      S Offline
                      Sukkeralf
                      wrote on sidst redigeret af
                      #116

                      If Genmab want and ADC for instance they need to partner up with a ADC company like everyone else

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                      • JørgenVarnæsJ Offline
                        JørgenVarnæsJ Offline
                        JørgenVarnæs
                        wrote on sidst redigeret af
                        #117

                        Apart from hexa - when was the last time we saw results from the clinic on new programs?

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                        • S Offline
                          S Offline
                          Sukkeralf
                          wrote on sidst redigeret af
                          #118

                          Thats a good thing I think - different targets needs different tech

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                          • JørgenVarnæsJ Offline
                            JørgenVarnæsJ Offline
                            JørgenVarnæs
                            wrote on sidst redigeret af
                            #119

                            how is KYSO the same as the need to enter 50/50 partnerships to get something off the ground?

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                            • E Offline
                              E Offline
                              E_L
                              wrote on sidst redigeret af
                              #120

                              on ADC; to be honest, i had expected something from their collaboration with Abbvie there, Jan was very enthusiastic at the time on Abbvie's ADC technology

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                              • E Offline
                                E Offline
                                E_L
                                wrote on sidst redigeret af
                                #121

                                but we haven't seen anything with Abbvie really besides epco

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                                • E Offline
                                  E Offline
                                  E_L
                                  wrote on sidst redigeret af
                                  #122

                                  JV, epco was 50/50 after initial development

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                                  • E Offline
                                    E Offline
                                    E_L
                                    wrote on sidst redigeret af
                                    #123

                                    they stopped a few programs, eg HexaBody-DR5/DR5
                                    , DuoHexabody-CD37, DuoBody-CD3x5T4

                                    ,

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                                    • E Offline
                                      E Offline
                                      E_L
                                      wrote on sidst redigeret af
                                      #124

                                      that is not something you hope for in advance offcourse, ideally these would have gone further allready

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                                      • JørgenVarnæsJ Offline
                                        JørgenVarnæsJ Offline
                                        JørgenVarnæs
                                        wrote on sidst redigeret af
                                        #125

                                        EL, indeed. But where are all the other programs showing clinical promise?

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                                        • JørgenVarnæsJ Offline
                                          JørgenVarnæsJ Offline
                                          JørgenVarnæs
                                          wrote on sidst redigeret af
                                          #126

                                          So far we've seen nothing from the Biontech collab but vailed hints about synergistic effect. I can't point to a single thing in the pipeline with the potential to break through

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