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  4. Genmab — December 2024

Genmab — December 2024

Planlagt Fastgjort Låst Flyttet Genmab
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Denne tråd er blevet slettet. Kun brugere med emne behandlings privilegier kan se den.
  • StockBullS Offline
    StockBullS Offline
    StockBull
    wrote on sidst redigeret af
    #271

    der er en stigende debat om, hvordan sundhedssektoren og store medicinalfirmaer, der ikke integrerer AI i deres processer, kan miste konkurrenceevne. AI har potentiale til at revolutionere forskning, diagnose og behandling, hvilket kan give dem, der omfavner teknologien, en betydelig fordel. Investorer er ofte på udkig efter virksomheder, der innoverer og tilpasser sig nye teknologier, hvilket kan påvirke aktiekurserne i fremtiden. Håber Genmab køre fuld skrue m.h.t at implementere AI

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    • R Offline
      R Offline
      Raun
      wrote on sidst redigeret af
      #272

      Det er meldt ud for et stykke tid siden at Genmab satser stort på AI

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      • R Offline
        R Offline
        Raun
        wrote on sidst redigeret af
        #273

        Link Preview Image
        Genmab vil udvide AI-afdeling

        Hisham Hamadeh, der er global chef for datavidenskab og AI i Genmab, forventer at 2025 bliver et vendepunkt.

        favicon

        (medwatch.dk)

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        • E Offline
          E Offline
          E_L
          wrote on sidst redigeret af
          #274

          ASH24 718 Safety and Efficacy of Mim8 Prophylaxis Administered Once Every Two Weeks for Patients with Hemophilia A with or without Inhibitors: Interim Analysis of the FRONTIER4 Open-Label Extension Study https://ash.confex.com/ash/2024/webprogram/Paper198617.html

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          • E Offline
            E Offline
            E_L
            wrote on sidst redigeret af
            #275

            Tadashi Matsushita, MD, PhD: Reducing Treatment Burden in Hemophilia A - findings from the OLE FRONTIER4 study of Mim8. https://www.hcplive.com/view/matsushita-reducing-treatment-burden-hemophilia-a

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            • E Offline
              E Offline
              E_L
              wrote on sidst redigeret af
              #276

              ASH24 1212 Mim8 Prophylaxis Beyond Bleeding: Investigating Multifaceted, Patient-Reported Outcomes for Hemophilia A in the FRONTIER2 Study https://ash.confex.com/ash/2024/webprogram/Paper198395.html

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              • E Offline
                E Offline
                E_L
                wrote on sidst redigeret af
                #277

                Mim8 Improved Patient Outcomes in Hemophilia A in FRONTIER2 Trial https://www.rarediseaseadvisor.com/news/mim8-improved-patient-outcomes-in-hemophilia-a-in-frontier2-trial/

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                • E Offline
                  E Offline
                  E_L
                  wrote on sidst redigeret af
                  #278

                  Tri-specific Antibody SAR442257 in RRMM - further development halted

                  • https://www.youtube.com/watch?v=7NzP-E9WnRo
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                  • G Offline
                    G Offline
                    gentogen
                    wrote on sidst redigeret af
                    #279

                    This Phase 1 study of SAR'257 showed an anti-tumor response in a small number of pts from the rrMM and rrNHL cohorts. Due to safety concerns, in particular high rates of EBV and CMV reactivation and recurrent episodes of CRS in the higher dose levels, the study was terminated during dose escalation

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                    • G Offline
                      G Offline
                      gentogen
                      wrote on sidst redigeret af
                      #280

                      the overall response rate (ORR), defined as partial response (PR) or better, was 5%......

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                      • E Offline
                        E Offline
                        E_L
                        wrote on sidst redigeret af
                        #281

                        ASH24 T Cells from CLL Patients on Venetoclax Mount Potent Cytotoxic Responses in
                        Combination with Epcoritamab, a CD20/CD3 Bispecific Antibody https://www.postersessiononline.eu/173580348_eu/congresos/ASH2024/aula/-SUN_3231_ASH2024.pdf https://ashpublications.org/blood/article/144/Supplement 1/3231/533852/T-Cells-from-CLL-Patients-on-Venetoclax-Mount

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                        • E Offline
                          E Offline
                          E_L
                          wrote on sidst redigeret af
                          #282

                          further ASH24 presentations /posters via https://www.genmabmedicalaffairs.com/congress?filv1=21

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                          • nohopeN Offline
                            nohopeN Offline
                            nohope
                            wrote on sidst redigeret af
                            #283

                            Hypotese: JnJ meddeler, at Erzo er interessant, men kun til halvdelen af den royalty, som der var aftalt ?

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                            • E Offline
                              E Offline
                              E_L
                              wrote on sidst redigeret af
                              #284

                              i have had something like this in the back of my mind as well. it may not be a binary yes or no decision, there may be a gray zone where either JNJ or Genmab tries to adjust the agreement... but that really is a futile discussion for now, until we'll hear what happens

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                              • E Offline
                                E Offline
                                E_L
                                wrote on sidst redigeret af
                                #285

                                at the end of the day, there is a legal document; if JNJ only wants to pay half Genmab can say no if they think they can make more money with it themselves. they'll have to make a choice.

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                                • nohopeN Offline
                                  nohopeN Offline
                                  nohope
                                  wrote on sidst redigeret af
                                  #286

                                  Selv halv betaling ville være mere end GENMAB kunne opnå ved selv at promovere Erzo i andre indikationer.

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                                  • E Offline
                                    E Offline
                                    E_L
                                    wrote on sidst redigeret af
                                    #287

                                    We don't know that. I argued here before that it may very well be that it is actually more valuable in the hands of genmab. But at a greater risk. But only genmab has a reasonable insight into this. My preference for now is for jnj to opt in as that
                                    may be most beneficial for short term stock prices

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                                    • SolsenS Offline
                                      SolsenS Offline
                                      Solsen
                                      wrote on sidst redigeret af
                                      #288

                                      In that case its a NO from Genmab. The decision is binary. Is Erzo interesting or no and the terms we have discussed.

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                                      • SolsenS Offline
                                        SolsenS Offline
                                        Solsen
                                        wrote on sidst redigeret af
                                        #289

                                        No more gifts to JNJ.

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                                        • J Offline
                                          J Offline
                                          Jhonnykuskus
                                          wrote on sidst redigeret af
                                          #290

                                          Helge har også fint argumenteret i én af sine videoer. At JnJ nok ikke ville kunne have råd til at sige nej. I så fald hvis hexabody viser sig at være bedre end dara. Det jeg har fundet og skrevet i mine noter fra et clinical studie om hexabody er begrænset, da det jo var en lille kohorte. Men at der er en tolerabel bivirkningsprofil. Neutropeni var den hyppigste. Og den er at behandle (Ser man også ved andre patienter).

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