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  4. Genmab — Oktober 2024

Genmab — Oktober 2024

Planlagt Fastgjort Låst Flyttet Genmab
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Denne tråd er blevet slettet. Kun brugere med emne behandlings privilegier kan se den.
  • G Offline
    G Offline
    gentogen
    wrote on sidst redigeret af
    #850

    Altså i al almindelighed. Her ved vi jo, at de kommer

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    • E Offline
      E Offline
      E_L
      wrote on sidst redigeret af
      #851

      Q3-2024-PFE-Earnings-Release Pizer Tivdak $34 (32 US, 2 international) https://s28.q4cdn.com/781576035/files/doc_financials/2024/q3/Q3-2024-PFE-Earnings-Release-Final.pdf

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      • E Offline
        E Offline
        E_L
        wrote on sidst redigeret af
        #852

        Exclusive: Genmab lines up T cell engager pact with Revitope Oncology https://endpts.com/exclusive-genmab-lines-up-t-cell-engager-pact-with-revitope/ https://www.revitope.com/

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        • E Offline
          E Offline
          E_L
          wrote on sidst redigeret af
          #853

          3 targets, Genmab pays $9mn upfront with potential milestones up to $600mn, solid tumors

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          • B Offline
            B Offline
            bikube
            wrote on sidst redigeret af
            #854

            Er Tivdak stadig kun i 3. line. ?

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            • E Offline
              E Offline
              E_L
              wrote on sidst redigeret af
              #855

              yes. and only US and since this summer Macau, (not yet in mainland China). i assume that is where the $
              2mn international is from, or maybe off-label. EU and Japan submitted this year.

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              • E Offline
                E Offline
                E_L
                wrote on sidst redigeret af
                #856

                We are waiting to see if they will proceed with trials for head and neck cancer which was one of the goals for this year, but seems a bit less certain after a recent evasive
                remark by Klimovsky

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                • E Offline
                  E Offline
                  E_L
                  wrote on sidst redigeret af
                  #857

                  Where i first thought that maybe Pfizer would be less interested in furthere Tiso development, now it could certainly also be Genmab after the addition of the Profound bio portfolio. If they really think toxicity is less with those ADC's then it is with Tiso ,
                  it may be smart to invest the money there...

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                  • E Offline
                    E Offline
                    E_L
                    wrote on sidst redigeret af
                    #858

                    a few changes in the GEN1046 Safety Trial write up. Also completion dates delayed (again) by a year this time; I wonder, given that they already stopped recruiting early this year, could that mean that patients stay on the drug longer than expected? or how should we look at this? https://clinicaltrials.gov/study/NCT03917381?tab=history&a=35&b=36#version-content-panel

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                    • B Offline
                      B Offline
                      bikube
                      wrote on sidst redigeret af
                      #859

                      Thanks E L.

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                      • E Offline
                        E Offline
                        E_L
                        wrote on sidst redigeret af
                        #860

                        GEN1047 set to Active not recruiting at 179 actual patients vs 400 expected, so I guess that doesn't look good? Not a very big surprise , was expecting news this quarter, let's see if they can give an update next week
                        https://clinicaltrials.gov/study/NCT05180474?tab=history&a=16&b=17#version-content-panel

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                        • E Offline
                          E Offline
                          E_L
                          wrote on sidst redigeret af
                          #861

                          large new Amivantamab Ph3
                          trial Versus Cetuximab as First-line Treatment in Participants With KRAS/​NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer (OrigAMI-2) https://clinicaltrials.gov/study/NCT06662786

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                          • L Offline
                            L Offline
                            lahn1
                            wrote on sidst redigeret af
                            #862

                            Tivdak er da godkendt i 2L cervical cancer med accelerate approval og 3 L SCCHN not ?

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                            • E Offline
                              E Offline
                              E_L
                              wrote on sidst redigeret af
                              #863

                              sorry, i stand corrected, misread the question, approved 2L+, not yet in first line

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                              • E Offline
                                E Offline
                                E_L
                                wrote on sidst redigeret af
                                #864

                                i think innovaTV 207 also ahs an arm for first line head an neck even if i am not mistaken lahn? (next to
                                2L+

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                                • E Offline
                                  E Offline
                                  E_L
                                  wrote on sidst redigeret af
                                  #865

                                  Genmab indgår partnerskab med amerikansk kræftfirma

                                  -Revitope Oncology https://medwatch.dk/Medicinal___Biotek/article17585749.ece

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                                  • L Offline
                                    L Offline
                                    lahn1
                                    wrote on sidst redigeret af
                                    #866

                                    Yes innovaTV207 arm F and G respectively Tivdak+Ketruda and the same + carboplatin i 1L SCCHN

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                                    • E Offline
                                      E Offline
                                      E_L
                                      wrote on sidst redigeret af
                                      #867

                                      ok. i assume we'll hear about plans for a potential new Ph3 trial next week, as the goal was to start it in 2024...

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                                      • L Offline
                                        L Offline
                                        lahn1
                                        wrote on sidst redigeret af
                                        #868

                                        on the last investor call my impression from Jan was that he would want to go ahead in with. ph3 but pending on PFE. But Tox is very high so maybe..... as you said minutes ago reg. Profound

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                                        • L Offline
                                          L Offline
                                          lahn1
                                          wrote on sidst redigeret af
                                          #869

                                          Hvad sker der med Gen1046. Udskudt 12 mdr. Ny tekst siger at, The average trial duration for an individual subject will be about 74 weeks. 17,6 mdr. som vi så på ASCO. Så tror v det overraskende gode OS holder ?. Hvad siger 21 weeks treatment duration os ? fortæller et noget om median DoR ? som ikke var nået på ASCO

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