Genmab — Marts 2021

[E_L]

troldmanden are you essentially saying they can estimate toxicity already in those preclinical models? (i can understand efficacy, but thought you would need it in human to find out how toxic it is?)

[troldmanden]

We always need human trials. But its to closly related molecules, so there is a lot that can be compared in preclinical models vs dara clinical data

[troldmanden]

two closely....

[GeorgeBest]

14:13 @Bulder: men referencen til subcu kan jo være relateret til Mosunetuzumab, hvor vi har vist siden sidste efterår at Roche vil udvikle en subcu version

[Bulder]

Det kan være. Jeg ved ikke specifikt om glofi.

[E_L]

New smal trial - An Open Label Study to Evaluate Daratumumab in Participants With Moderate to Severe Systemic Lupus Erythematosus (DARALUP) https://clinicaltrials.gov/ct2/show/NCT04810754?term=genmab+OR+daratumumab+OR+darzalex+OR+ofatumumab+OR+Teprotumumab+OR+Tisotumab+OR+camidanlumab+OR+Enapotamab+OR+ADCT-301+OR+duobody+OR+hexabody+OR+Teclistamab+OR+Amivantamab+OR+Talquetamab+OR+Epcoritamab+OR+DuoHexabody&lupd_s=03%2F23%2F2021&draw=2&rank=1

[E_L]

we had a few articles indicating Dara would work here and in september an article where this Berlin hospital announced they would start a trial

[Helge_LarsenPI-redaktør]

Q&A starter kl. 15,30.

[Solsen]

SLE er en oplagt indikation for dara, som man ikke forstår hvorfor JNJ ikke har angrebet.

[Solsen]

NBI nede med 2,5% og Genmab kun 1% ... positivt

[svak]

Hvor følger vi o&a - der er ikke noget under fanen?

[exitnu]

Her: https://www.proinvestor.com/chathistory/-133/qa-genmab-2021-03-23

[svak]

tak -
exitnu

[Solsen]

Hexa38 lyder super interessant på Q&A

[peter12]

Ja og han lyder optimistisk

[Mcjean]

Yep det eneste tidspunkt han havde sin "det kører bare" hat på:-)

[Solsen]

Jeg tvivler stærkt på at HALO skal involveres i hexacd38

[Solsen]

Hvad mon CT siger

[E_L]

IV offcourse for now

[E_L]

and then hope the dose they end up with is small enough to put it through in SC