Genmab — December 2020

E_L

A Multicenter Study to Assess Response to Influenza Vaccine in Multiple Sclerosis Participants Treated With Ofatumumab https://clinicaltrials.gov/ct2/show/NCT04667117?term=genmab+OR+daratumumab+OR+darzalex+OR+ofatumumab+OR+Teprotumumab+OR+Tisotumab+OR+camidanlumab+OR+Enapotamab+OR+ADCT-301+OR+duobody+OR+hexabody+OR+Teclistamab+OR+Amivantamab+OR+Talquetamab+OR+Epcoritamab+OR+DuoHexabody&lupd_s=12%2F12%2F2020&draw=2&rank=1

Bulder

Not long ago it was published in some MS-news that Ocrevus might have this issue with loss of vaccinal immunity. I assume that's why Novartis wants to find out whether that goes for ofa as well. Would not be good. Especially if it is also an issue with the corona vaccines.

Bulder

I asked Winkel about it in August, but he didn't answer.

Bulder

But evidence shows that some patients given vaccines to protect against the influenza virus or pneumococcal bacteria lose such immunity after Ocrevus treatment. https://multiplesclerosisnewstoday.com/news-posts/2020/08/21/ocrevus-eliminates-vaccine-immunity-to-varicella-zoster-virus-rrms-patient-case-report/

E_L

It is an issue. We can hope that the way Kesimpta is administered and dose will have less B cell depletion and faster recovery in the case of a pause in treatment; if that is the case Kesimpta would be the preferred drug vs Ocrevus

E_L

i am sure Novartis is getting a lot of questions about this at the moment and I see the trial above just as much in the light of the covid vaccine as the influenze (as i guess you do)

Rondo

Ja ja så banker vi på igen igen ....:-)

E_L

anyone following Novo know more about that new company? Will Mim8 move there for example? Will the Duobody licence move there fully, or will Novo nordisk still have access?

Bulder

I wonder if it is an issue with weakened virus vaccines only, and not with those based on mRNA?

E_L

I can't answer that i am afraid...and i doubt Novartis will be able to do any trials on these vaccines until things settle down and vaccines will be widely available, I think we'll have to do with the influenza as substitute for now...

E_L

there will be quit a few drugs that have this issue...

Bulder

Igen i dag hjalp det på både omsætning og kurs, at usa kom til undsætning.

E_L

Novo invests in Hemab @endpointsnews https://endpts.com/novo-invests-in-hemab-a-company-going-against-the-hemophilia-gene-therapy-grain-with-a-plan-for-bispecifics/

Doublo

Jeg har proxy error og kan ikke komme ind på Nordnet, oplever I det samme?

Bulder

brug det gamle

Doublo

hvordan mener du? jeg kan slet ikke komme ind.

nohope

Ditto her.

Bulder

det gamle nordnet virker

AaBforever

Jeps.. men problemet er at du kun kan komme på det gamle via det nye.

AaBforever

Jeg bruger stadig mest det gamle.