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Genmab — Oktober 2020

Planlagt Fastgjort Låst Flyttet Genmab
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Denne tråd er blevet slettet. Kun brugere med emne behandlings privilegier kan se den.
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    GeorgeBest
    wrote on sidst redigeret af
    #316

    Any opinion about the liver tox in GEN1046?

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      E_L
      wrote on sidst redigeret af
      #317

      "sorry can't tell you; it is under embargo"
      😉

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        E_L
        wrote on sidst redigeret af
        #318

        There was transaminise elevation , 24.6% all grades, 9.8% grade 3-4

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          E_L
          wrote on sidst redigeret af
          #319

          treatment related grade-3 transaminase elevatoins decreased upon corticosteroid administration, no treatment related bilirubin increases or grade-4 transaminase elevatoins occured

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            E_L
            wrote on sidst redigeret af
            #320

            so in summary they concluded manageable safety profile

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              GeorgeBest
              wrote on sidst redigeret af
              #321

              Thank you, there were some doubts from Nordea, but very impressive on efficiacy on those heavily pretreated patients they apparently concluded

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                E_L
                wrote on sidst redigeret af
                #322

                did Nordea base their doubts on that abstract?

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                  GeorgeBest
                  wrote on sidst redigeret af
                  #323

                  Yes

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                    GeorgeBest
                    wrote on sidst redigeret af
                    #324

                    I have not seen the note myself, but 6 patients had dose limiting tox incl elevated liver enzymes they write

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                      GeorgeBest
                      wrote on sidst redigeret af
                      #325

                      Liver tox have in the past been a problem and hindernis for 4-1BB drugs, and therefore this has to be monitored closely they conclude

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                        E_L
                        wrote on sidst redigeret af
                        #326

                        yes, offcourse

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                          E_L
                          wrote on sidst redigeret af
                          #327

                          6 out of 61, treatment with corticosteroid seems to help, maximum tolerated dose was not reached

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                            E_L
                            wrote on sidst redigeret af
                            #328

                            exactly because liver tox was an issue before, I was not disappointed with this. Surely we'll hear a bit more about this in november

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                              E_L
                              wrote on sidst redigeret af
                              #329

                              i posted a picture of the abstract on twitter by the way, you can check there (until they take me down 😉

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                                GeorgeBest
                                wrote on sidst redigeret af
                                #330

                                I have seen it, thank you.

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                                  GeorgeBest
                                  wrote on sidst redigeret af
                                  #331

                                  A bit dissapointing that there haven‘t been any comments from oncologists so far

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                                    E_L
                                    wrote on sidst redigeret af
                                    #332

                                    i don't think anyone has seen the data really, i wouldn't worry about that

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                                      E_L
                                      wrote on sidst redigeret af
                                      #333

                                      any thoughts/speculations on that new Talquetamab/Teclistamab trial? I guess we have to see this in the context of the existing trial combining them with Dara? But that started only in February, I doubt they have seen any real data on that yet? https://clinicaltrials.gov/ct2/show/NCT04108195

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                                        AaBforever
                                        wrote on sidst redigeret af
                                        #334

                                        Kursmålet på Genmab-aktien er torsdag blevet hævet til 2500 kr. fra tidligere 1750 kr. af finanshuset Kempen & Co. Anbefalingen lyder fortsat på køb./ritzau/FINANS

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                                        • SolsenS Offline
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                                          Solsen
                                          wrote on sidst redigeret af
                                          #335

                                          Media Release

                                          Copenhagen, Denmark, October 15, 2020

                                          Genmab will host Capital Markets Day November 13, 2020
                                          Highlights to be covered will include an overview of our pipeline with focus on epcoritamab, tisotumab vedotin and DuoBody®-PD-L1x4-1BB, our DuoBody® technology platform, and insights into our growing capabilities across Genmab

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