Genmab — Juni 2020

[GeorgeBest]

Patienten, die an dieser Phase-I-Studie teilgenommen haben, hatten zuvor bereits im Schnitt drei andere Therapien erhalten.
Beim Kandidaten Glofitamab, der zuvor als CD20-TCB bekannt war, handelt es sich laut Mitteilung um einen bispezifischen, an T-Zellen andockenden CD20xCD3-Antikörper.

[GeorgeBest]

Glofitamab https://twitter.com/kkmaggon/status/1271407632331550724?s=21

[Bulder]

dauerhaft und vollständig - men hvor mange?

[nohope]

Just-in-time: Pølsemanden serverer 4 pølser hverdag kl. 12.15 2 stk. med sennep og 2 stk. med ketchup. On-demand: Pølsemanden serverer pølser efterhånden som kunderne forespørger det, med ketchup, uden ketchup, med ristede løg, uden ristede løg.

[gentogen]

Mere ketchup, tak

[Helge_LarsenPI-redaktør]

Finans.dk....Suk! https://twitter.com/HelgeLarsen2/status/1271418388800327681

[gentogen]

Sprøjt

[E_L]

https://twitter.com/DocHutchings/status/1271422728604659717

[Bulder]

No news as far as I can see

[gentogen]

Så vidt jeg kan tyde det, står der data cut off for efficacy var 14. maj (så kun få dage mere end sidst)

[gentogen]

Fra Roche: https://www.roche.com/dam/jcr:148d9556-2384-4399-8768-2e59aec09dc1/en/200612-ir-glofitamab-eha-stage3-approved.pdf

[E_L]

OR for DLBCL now 60%, was 50% , 1 more patient (15 vs 14)

[E_L]

and
1 patient went from Stable disease to Partial response

[E_L]

it also says "the emerging favourable safety profile of epcoritamab suggests that it has the potential for outpatient administration"

[E_L]

that would be fantastic

[Mcjean]

Tell it to the insulted danish banks, maybe they will raise stockprice with 10 kr.

[Bulder]

But glofitamab's CR-rates look impressive.

[Bulder]

Median prior lines = 3 for both

[E_L]

yes. even though a bit more toxic?

[E_L]

and it seems higher dose for glofitamab do not make a lot of difference?