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Genmab — April 2020

Planlagt Fastgjort Låst Flyttet Genmab
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  • S Offline
    S Offline
    Sukkeralf
    wrote on sidst redigeret af
    #771

    E L could it be combined with CD20/CD3 or just CD20 antibodies - again maybe important for a epcoritamab deal if DuoHexa-CD37 should be included

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    • S Offline
      S Offline
      Sukkeralf
      wrote on sidst redigeret af
      #772

      But maybe Genmab want to see some data before they decide if it should part
      nered up

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      • E Offline
        E Offline
        E_L
        wrote on sidst redigeret af
        #773

        interesting thoughts...
        -from both

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        • S Offline
          S Offline
          Sukkeralf
          wrote on sidst redigeret af
          #774

          My preferred partner would be Novartis or Janssen at the moment

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          • E Offline
            E Offline
            E_L
            wrote on sidst redigeret af
            #775

            i think we could all be happy with those

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            • troldmandenT Offline
              troldmandenT Offline
              troldmanden
              wrote on sidst redigeret af
              #776

              Helst ikke JnJ. Ikke for mange store æg i samme kurv....

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              • G Offline
                G Offline
                gentogen
                wrote on sidst redigeret af
                #777

                In the article (looks absolutely great) they also have a reference to this one; "CD20 And CD37 Antibodies Synergize To Activate Complement By Fc-Mediated Clustering". It also looks very promising: http://www.haematologica.org/content/104/9/1841

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                • G Offline
                  G Offline
                  gentogen
                  wrote on sidst redigeret af
                  #778

                  By the way, it looks like the first author Simone Oostindie is not only at Genmab but also works at the same place as Paul Parren

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                  • E Offline
                    E Offline
                    E_L
                    wrote on sidst redigeret af
                    #779

                    it is a University Medical Centre, in Leiden. Parren is a Professor there, maybe she is doing her Phd with him there

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                    • E Offline
                      E Offline
                      E_L
                      wrote on sidst redigeret af
                      #780

                      Usmani starts a small trial of Dara-Pembro for Heavily pre-treated Multiple Myeloma Patients https://clinicaltrials.gov/ct2/show/NCT04361851?term=genmab+OR+daratumumab+OR+darzalex+OR+ofatumumab+OR+Teprotumumab+OR+Tisotumab+OR+camidanlumab+OR+Enapotamab+OR+ADCT-301+OR+duobody&lupd_s=04%2F28%2F2020&draw=2&rank=5

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                      • G Offline
                        G Offline
                        gentogen
                        wrote on sidst redigeret af
                        #781

                        En detalje fra artikel: We speculate that combinations of DuoHexaBody-CD37 with pro-apoptotic PI3K-δ-inhibitors such as idelalisib may work synergistically,

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                        • SolsenS Offline
                          SolsenS Offline
                          Solsen
                          wrote on sidst redigeret af
                          #782

                          No doubt that CD37 could be huge. I have seen many articles about the synergy with CD20 but also CD37 alone. http://www.haematologica.org/content/104/9/1841 https://ashpublications.org/blood/article/132/Supplement 1/4170/275811/DuohexabodyCD37-a-Novel-Bispecific-Antibody-with-a and yes perhaps included in the bag in the coming partnerdeal.

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                          • Helge_LarsenPI-redaktørH Offline
                            Helge_LarsenPI-redaktørH Offline
                            Helge_LarsenPI-redaktør
                            wrote on sidst redigeret af
                            #783

                            Just a moment...

                            favicon

                            (www.proinvestor.com)

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                            • E Offline
                              E Offline
                              E_L
                              wrote on sidst redigeret af
                              #784

                              Novartis AG (NVS) CEO on Q1 2020 Results - Earnings Call Transcript https://seekingalpha.com/article/4340622-novartis-ag-nvs-ceo-vasant-narasimhan-on-q1-2020-results-earnings-call-transcript?part=single

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                              • E Offline
                                E Offline
                                E_L
                                wrote on sidst redigeret af
                                #785

                                quite a few comments/ questions on ofatumumab

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                                • G Offline
                                  G Offline
                                  GeorgeBest
                                  wrote on sidst redigeret af
                                  #786

                                  Sounds like Novartis will be very aggressive in maketing ofa in MS...

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                                  • T Offline
                                    T Offline
                                    transalp
                                    wrote on sidst redigeret af
                                    #787

                                    Go morgen.. 🙂

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                                    • B Offline
                                      B Offline
                                      bibob
                                      wrote on sidst redigeret af
                                      #788

                                      God morgen. 🙂

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                                      • H Offline
                                        H Offline
                                        Hamming
                                        wrote on sidst redigeret af
                                        #789

                                        Link Preview Image
                                        PharmiWeb.com – Thank you

                                        After twenty-five years, PharmiWeb.com is closing. A note of thanks to the pharmaceutical industry community that built it.

                                        favicon

                                        (www.pharmiweb.com)

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                                        • H Offline
                                          H Offline
                                          Hamming
                                          wrote on sidst redigeret af
                                          #790

                                          Enapotamab er "
                                          next up"

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