Genmab — Januar 2020
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Ok. So we are back to Dara in solids. Let's hope it goes better than the last time
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Thank you E L. Do they know anything about the timeframe for this?
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Plimsoller..We must remember that the failed attempt in solid was a combination. Dara may work as intended, but the other drugs can have powerful side effects.
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Ok. Thank you for the explanation to both of you
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Daratumumab to Enhance Therapeutic Effectiveness of Revlimid in Smoldering Myeloma https://clinicaltrials.gov/ct2/show/NCT03937635
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Sidst sagde han således: vi afventer ivrigt de kliniske data fra den igangværende undersøgelse (Isatuximab in combination with Atezolizumab in a number of solid tumors) før vi bestemmer de næste trin for Dara i potentiel behandling af faste kræftformer. Altså underforstået at man overvejer at starte op igen.
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I Checkmate358 er rekruttering stoppet i dara-armen. Andre dele af studiet kører videre. Checkmate142 (tyktarmskræft) rekrutterer ikke længere, men studiet er aktivt. Resultater nok ikke før 2022. Det "rene" dara-nivo studie i diverse solide rekrutterer heller ikke, men er aktivt. Resultater måske til august. Dette er det eneste studie, hvor der kunne tænkes at være en lille dør på klem til snarlige resultater.
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