Genmab — December 2018

[JKY_VH]

Ja bibob, det virker påfaldende tilfældigt:-D

[Sukkeralf]

Just a moment...

(www.firstwordpharma.com)

[Solsen]

Gad vide hvorfor så mange sætter spørgsmålstegn til OS ?

[Thomas]

Interessant, Sukkeralf. Gad vide hvad det løber op i at købe resultaterne. Jeg har skrevet mig op så jeg får en e-mail når resultaterne løber ind og så kan man købe sig adgang til dem

[E_L]

are they worried about actual OS, or that measuring statistically significant OS is impossible due to dara follow-on treatment ?

[E_L]

over ASH we heard ´Importantly, this study did demonstrate that despite the significant improvement with daratumumab in the initial PSF1, it did not impact the response of the patient in the next line of therapy. Therefore, the PSF2 was improved in the daratumumab arm."´

[E_L]

as in this article on Pollux https://www.raredr.com/conferences/ash-2018/nizar-bahlis-md-recaps-followup-trial-showing-combo-therapy-rr-multiple-myeloma-maintains-high-response-rates-

[Solsen]

You are right. But why do we still se some uncertainty to that fact.

[Bulder]

As I see it, the problem is that you'll never get valid OS comparison between DRd and Rd as pts in the Rd-arm, when they relapse, naturally will prefer DRd (Pollux) to continue with.

[Bulder]

Or, if they are refractory to R, then DVd.

[E_L]

seems like a bit of a luxury problem…

[Solsen]

Yes but still some KOL questions daras use in first line. To me only price is the question. If its no problem then we se $10 bn without question

[Bulder]

There are doctors with the attitude "save the best for later", who for that reason will not use dara frontline. It's still to be seen how many they are.

[pauly]

Rimeligt skørt at have den holdning

[E_L]

yea, that is a job for the JNJ sales force... We had research showing the importance of best treatment first... they will have to push that…

[Solsen]

Certainly a job for JNJ. JW seems confident in winning the battle. 50% instant rise in sales

[troldmanden]

Det har aldrig rigtig givet mening forr mig med det her 50% stigning straks der ligger en godkendelse i 1. line. Hvorffor ikke....? Nu har dde talt om forever at der var stolemangle. Det har været en slags "undskyldning" for væksten ikke har været bedre den seneste tid

[troldmanden]

HVIS det er rigtig vil godkendelse i 1. linee jo iikke løse noget. Så er den ved at ramme et platatueu? Altså at det er SC der skal til for reelt at løfte den meget højere

[troldmanden]

Det virker llidt som at blæse og haave mel i munden samme tid

[Tandfeen-2]

JW mente vækst stiger med 50%, altså fra 28mio USD pr mdr til 42mio uds= 3,4 mia USD i 2019.... så til årsregnskab guider han 3- 3,5 mia USD.= kurs 1500-2000