Genmab — November 2018
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Det er set før, at man har ændret i protokollen efter start. Men en så gennemgribende som administrationsmåden gør man næppe. I øvrigt er det jo et ISS-studie - og ikke Janssen - som går ud på at finde ud af hvordan dara og Venetoclax spiller sammen og ikke om sc er bedre end iv. Førtst i det øjeblik at sc er blevet standard vil man bruge det - vil jeg tro.
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On the SITC abstracts @peter12 linked to last week (pdf https://higherlogicdownload.s3.amazonaws.com/SITCANCER/7aaf41a8-2b65-4783-b86e-d48d26ce14f8/UploadedImages/Annual_Meeting_2018/Annual_Meeting/SITC_2018_Abstract_Book.pdf ) P5 also interesting Anti-CD38 immunotherapy kills Treg
(CD4+CD25+FoxP3+CD38hi) and Breg
(CD19+CD24+CD38hi) cells and restores the antitumor
T-cell repertoire in chronic lymphocytic
leukemia (CLL). -
Conclusions
Anti-CD38 immunotherapy is lethal to
immunosuppressive CD38hi Breg/Treg cells and may
improve anti-tumor T-cells function via modulating
CLL immune-microenvironment. The results of these
analyses have led to the approval of a phase-II
clinical study that will be testing Dara in
relapsed/refractory CLL patients. -
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Super. Tak for link.
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