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Genmab — November 2018

Planlagt Fastgjort Låst Flyttet Genmab
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  • SolsenS Offline
    SolsenS Offline
    Solsen
    wrote on sidst redigeret af
    #295

    Man er klar over hvilke problemer, der er med CAR-t og arbejder naturligt nok med forbedringer https://ash.confex.com/ash/2018/webprogram/Paper119247.html

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    • SolsenS Offline
      SolsenS Offline
      Solsen
      wrote on sidst redigeret af
      #296

      Daras safety og sc versionens forbedring er guld værd !

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      • P Offline
        P Offline
        Plimsoller
        wrote on sidst redigeret af
        #297

        Men havde analytikerne
        ment at CAR-t ville snuppe en stor del af markedet, så ville de vel have skåret i topsalgsestimatet for Dara?

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        • SolsenS Offline
          SolsenS Offline
          Solsen
          wrote on sidst redigeret af
          #298

          Flere amalytikere ævler om at car-t truer salget. De burde sætte dara ind i firstline med gennemsnitlig behandlingstid på 50-70 mdr. Så skulle de se løjer i regnearket.

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          • P Offline
            P Offline
            Plimsoller
            wrote on sidst redigeret af
            #299

            Enig Solsen, men jeg undrer mig lidt over at de (på trods af CAR-t begejstringen), ikke decideret skærer ned på Dara topsalgsestimatet. Det giver ikke mening.

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            • E Offline
              E Offline
              E_L
              wrote on sidst redigeret af
              #300

              .@Solsen 19.21 , i was a bit surprised ADCT 301 wasnt in the press release. Genmab owns 25% I think?

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              • SolsenS Offline
                SolsenS Offline
                Solsen
                wrote on sidst redigeret af
                #301

                Yes. Do you know the royalty ?

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                • G Offline
                  G Offline
                  gentogen
                  wrote on sidst redigeret af
                  #302

                  Ofatumumab was active and safe in these elderly chemoimmunotherapy-treated patients with SMZL. IRRs were generally mild and easily manageable, even in a cohort of patients with a very high median age and a relevant comorbidity burden. The ORR and the CR rate compare favorably with data reported in the literature with rituximab monotherapy also considering that >75% of patients have been previously exposed to rituximab.

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                  • BulderB Offline
                    BulderB Offline
                    Bulder
                    wrote on sidst redigeret af
                    #303

                    They get 25% of the income I suppose?

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                    • SolsenS Offline
                      SolsenS Offline
                      Solsen
                      wrote on sidst redigeret af
                      #304

                      I belive I reffered to the seach results. It was in 5 oral abstracts ACDT 301 was mentioned.

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                      • SolsenS Offline
                        SolsenS Offline
                        Solsen
                        wrote on sidst redigeret af
                        #305

                        Didnt they switch to a royalty when leave the opt.in.

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                        • G Offline
                          G Offline
                          gentogen
                          wrote on sidst redigeret af
                          #306

                          The combination of ofatumumab, HDMP and lenalidomide is effective and well tolerated in treatment-naive CLL/SLL, even when poor prognostic features are present.

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                          • E Offline
                            E Offline
                            E_L
                            wrote on sidst redigeret af
                            #307

                            this is what the genmab website says, http://www.genmab.com/product-pipeline/products-in-development/adct-301

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                            • BulderB Offline
                              BulderB Offline
                              Bulder
                              wrote on sidst redigeret af
                              #308

                              Genmab still owns 25% of the rights

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                              • E Offline
                                E Offline
                                E_L
                                wrote on sidst redigeret af
                                #309

                                "While we have decided not to fund co-development of HuMax-TAC-ADC with ADC Therapeutics, we are pleased to still have 25% of the rights to the product, which has potential to become a first-in-class antibody-drug conjugate therapeutic in certain hematological cancer indications," said Jan van de Winkel, Ph.D., Chief Executive Officer of Genmab. https://ir.genmab.com/news-releases/news-release-details/genmab-retains-partial-rights-humax-tac-adc-will-not-exercise-co

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                                • SolsenS Offline
                                  SolsenS Offline
                                  Solsen
                                  wrote on sidst redigeret af
                                  #310

                                  Thanks - Genmab could buy the co 😉

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                                  • E Offline
                                    E Offline
                                    E_L
                                    wrote on sidst redigeret af
                                    #311

                                    haha, let´s ask JV what he thinks of that idea

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                                    • SolsenS Offline
                                      SolsenS Offline
                                      Solsen
                                      wrote on sidst redigeret af
                                      #312

                                      I think he could se the synergy with the salesforce 😉

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                                      • E Offline
                                        E Offline
                                        E_L
                                        wrote on sidst redigeret af
                                        #313

                                        😉

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                                        • JørgenVarnæsJ Offline
                                          JørgenVarnæsJ Offline
                                          JørgenVarnæs
                                          wrote on sidst redigeret af
                                          #314

                                          Salesforce staves med stort S

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