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Genmab — Marts 2018

Planlagt Fastgjort Låst Flyttet Genmab
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  • A Offline
    A Offline
    AaBforever
    wrote on sidst redigeret af
    #759

    Hvor langt vi kommer over 400 mill. i Q1

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    • E Offline
      E Offline
      E_L
      wrote on sidst redigeret af
      #760

      after reaching €50mio, Dara lost Orphan status in Germany, leading to "eine Bekanntmachung" from the "Bundesministerium für Gesundheit" 😉 https://www.bundesanzeiger.de/ebanzwww/wexsservlet?session.sessionid=16a142094cdbe8edd5841e4fa803c0b8&page.navid=detailsearchlisttodetailsearchdetail&fts_search_list.selected=d747026b6b3fc404&fts_search_list.destHistoryId=16642 https://www.g-ba.de/informationen/nutzenbewertung/307/#tab/beschluesse

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      • E Offline
        E Offline
        E_L
        wrote on sidst redigeret af
        #761

        pdf https://www.g-ba.de/downloads/39-261-3222/2018-02-15_AM-RL_XII_Daratumumab_D-310_BAnz.pdf

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        • E Offline
          E Offline
          E_L
          wrote on sidst redigeret af
          #762

          not sure if it has any further practical implications , but the document shows a good insight in costs for the different combinations, eg Dara Len Dex 246.965,89 €, vs Dara Bor Dex 185.522,46 € "

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          • H Offline
            H Offline
            hda
            wrote on sidst redigeret af
            #763

            Ekstra Bladet om Darzalex salget i US i februar http://borsen.dk/nyheder/virksomheder/artikel/1/360281/genmab_darzalex-salget_faldt_i_usa_i_februar.html?utm_source=forside&utm_campaign=nyhed_03

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            • BulderB Offline
              BulderB Offline
              Bulder
              wrote on sidst redigeret af
              #764

              Solsen, har du kendskab til et sammenligningsgrundlag for OS i ALL? 12,9 mdr. lyder ikke af meget, men spm er hvad man har opnået med andre midler.

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              • S Offline
                S Offline
                Sukkeralf
                wrote on sidst redigeret af
                #765

                ALL er vist ret aggressiv - her Blincito data ved godkendelse. Ved ikke om patientgrundlaget er det samme:

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                • S Offline
                  S Offline
                  Sukkeralf
                  wrote on sidst redigeret af
                  #766

                  Document Moved

                  favicon

                  (www.amgen.com)

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                  • S Offline
                    S Offline
                    Sukkeralf
                    wrote on sidst redigeret af
                    #767

                    The approval is based on results from the TOWER study, which found that BLINCYTO demonstrated a superior improvement in median OS over standard of care (SOC) chemotherapy, nearly doubling median OS. The study showed that median OS was 7.7 months (95 percent CI: 5.6, 9.6) for BLINCYTO versus four months (95 percent CI: 2.9, 5.3) for SOC (hazard ratio for death=0.71; p=0.012). The approval is also based on data from the Phase 2 ALCANTARA study, which evaluated the efficacy of BLINCYTO in adult pat

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                    • S Offline
                      S Offline
                      Sukkeralf
                      wrote on sidst redigeret af
                      #768

                      Blincyto er CD19/CD3 så nok noget nær bedste sammenligning

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                      • S Offline
                        S Offline
                        Sukkeralf
                        wrote on sidst redigeret af
                        #769

                        with Ph+ relapsed or refractory B-cell precursor ALL.

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                        • S Offline
                          S Offline
                          Sibelius
                          wrote on sidst redigeret af
                          #770

                          TIlgengæld skriver Berlingske i dag i ena rtikel om stigende udgifter til ny medicin i DK at omkostningerne til Darzalex steg mere end 500% fra 2016 til 2017. Der blev købt for DKK 138 millioner i 2017.

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                          • BulderB Offline
                            BulderB Offline
                            Bulder
                            wrote on sidst redigeret af
                            #771

                            Ja, det ville have været rart med en kontrolgruppe, der fik SOC i car-t studiet. Ved du hvad det der Philadelphia chromosome-negative-halløj indebærer? Er de hårdere ramt i Blincytostudiet?

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                            • S Offline
                              S Offline
                              Sukkeralf
                              wrote on sidst redigeret af
                              #772

                              Ved det ikke Bulder, men umiddelbart vil jeg tro at de er hårdere ramt, men har som sagt intet at have det i

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                              • BulderB Offline
                                BulderB Offline
                                Bulder
                                wrote on sidst redigeret af
                                #773

                                Tak

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                                • SolsenS Offline
                                  SolsenS Offline
                                  Solsen
                                  wrote on sidst redigeret af
                                  #774

                                  Man skal være opmærksom på, at ALL CAR-T studiet rekrutterede omkirng 90 pts og de har kun samlet data på 53 pts. Så en hel del pts er udgået ?

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                                  • SolsenS Offline
                                    SolsenS Offline
                                    Solsen
                                    wrote on sidst redigeret af
                                    #775

                                    Udskylder hvis tallene er lidt forkerte men har ikke lige tid til at dyrke det 🙂

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                                    • SolsenS Offline
                                      SolsenS Offline
                                      Solsen
                                      wrote on sidst redigeret af
                                      #776

                                      Vi mangler i den grad en fornuftig kontrolarm !

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                                      • Legolas23L Offline
                                        Legolas23L Offline
                                        Legolas23
                                        wrote on sidst redigeret af
                                        #777

                                        Patienterne er vel døde...

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                                        • SolsenS Offline
                                          SolsenS Offline
                                          Solsen
                                          wrote on sidst redigeret af
                                          #778

                                          https://clinicaltrials.gov/show/NCT01044069 Der skulle optages 93 pts. Så 40 stks er måske døde eller frasorteret - who knows.

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