Genmab — Marts 2018

[E_L]

i would think you can safely assume that 1 dose of Dara SC will cost (at least) the same as 1 dose of Dara IV, irrespective of how much ml is in that dose

[Bulder]

Yes because the amount of dara is the same.

[Bulder]

For lige at præcisere: Mængden af dara er den samme (1800 mg) uanset om man blander manuelt med hyaluronidase på klinikken og får op til 90 ml, eller om man modtager det pre-mixed fra fabrikken i 15 ml færdige doser.

[Raffles]

På AACR har BMS et Abstract #2603 (….colorectal cancer treated with Nivolumab + Ipilimumab in checkmate -142, 16. april). De øvrige drugs (DARA og Cobimetinib) står dog ikke nævnt i overskriften!
Endvidere har de Abstract #1727 (antitumor actitity associated with dual targeting of CD38 and PD-1 pathways in preclinical models, 16. april).
Mon der kommer noget brugbart nyt d. 16. april??

[E_L]

i wast just reading this one " Furthermore, TTI-622 potentiates the efficacy of daratumumab and cetuximab in hematological and solid xenograft tumor models, respectively" http://www.abstractsonline.com/pp8/#!/4562/presentation/9327

[E_L]

that is the way to clarify it Bulder, thanks

[mobbyduck1]

Bergenbio er også med på AACH:

[mobbyduck1]

Bloomberg - Are you a robot?

(www.bloomberg.com)

[mobbyduck1]

AACR

[Bulder]

Checkmate 142 var et studie, der kørte i forvejen, og hvor dara blev hægtet på af BMS. Så der er sikkert ikke data endnu på dara-armen.

[E_L]

760 / 27 - Conjugation of daratumumab with 225actinium greatly increases its antitumor activity against multiple myeloma tumors
http://www.abstractsonline.com/pp8/#!/4562/presentation/9725

[Bulder]

Dara + en cd47-blokker - abstract 2709 - mindes jeg ikke at have set før. Til gengæld har vi nu set en del til blokade af pd-1 kombineret med et cd38 antistof.

[Bulder]

Den der med actinium adc var også med på ASH. Man kunne jo spørge Winkel på næste q&a om han kan se en dara+actinium adc for sig. E L?

[E_L]

5619 / 14 - Additional mechanisms of action of SGN-CD48A in multiple myeloma and improved antitumor activity in combination with daratumumab http://www.abstractsonline.com/pp8/#!/4562/presentation/8409

[Bulder]

Der er efterhånden en laang kø af stoffer, der bare længes efter at blive kombineret med dara.

[Bulder]

Interessant: " the combination of SGN-CD48A with daratumumab produced durable complete remissions in all animals. In contrast, combination of SGN-CD48A with elotuzumab did not produce additional antitumor activity. "

[E_L]

it will become increasingly difficult to keep track of all; but i guess that really is a luxury-problem

[bibob]

Next is Dara combined with Heineken.

[Bulder]

Yes we'll have to wait for the studies to become clinical studies. That will make the overview easier. But really encouraging that there are so many pre-clinical opportunities.

[E_L]

"no hang-over the day after" - would gaurantee triple-block-buster lol