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Genmab — Juli 2017

Planlagt Fastgjort Låst Flyttet Genmab
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Denne tråd er blevet slettet. Kun brugere med emne behandlings privilegier kan se den.
  • P Offline
    P Offline
    polle1
    wrote on sidst redigeret af
    #744

    God morgen 🙂

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    • M Offline
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      Mogan
      wrote on sidst redigeret af
      #745

      God morgen:-) Lidt læsning inden markedet åbner. https://www.nytimes.com/2017/07/23/health/gene-therapy-cancer.html?mwrsm=Email

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      • SolsenS Offline
        SolsenS Offline
        Solsen
        wrote on sidst redigeret af
        #746

        Vi kan nok godt være enige om at det ikke revolutionere glioblastoma behandlingen, desværre.

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        • M Offline
          M Offline
          Mogan
          wrote on sidst redigeret af
          #747

          Solsen: Enig, lang vej endnu.

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          • B Offline
            B Offline
            bibob
            wrote on sidst redigeret af
            #748

            Også enig Solsen. Glioblastoma er jo næsten det samme som en virus i selve kontrolcenteret i en computer. Meget svært at kontrollere og " rense ". Drugs skal virkelig være designet til opgaven. Måske med nanopartikler. ?

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            • B Offline
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              BiotechPro
              wrote on sidst redigeret af
              #749

              Carnegie genoptager dækning af GEN med Hold, target 1392

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              • B Offline
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                BiotechPro
                wrote on sidst redigeret af
                #750

                CAR: The current success of Darzalex for multiple myeloma has transformed the company. We expect revenue to reach DKK14.7bn in 2026, a compound annual growth rate of 20% from a base of DKK2.3bn in 2016. We estimate that 84% of revenue in 2026 will be based on Darzalex royalties. In multiple myeloma alone, we forecast unadjusted peak sales of USD8.6bn against consensus of about USD8bn.

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                • B Offline
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                  BiotechPro
                  wrote on sidst redigeret af
                  #751

                  CAR: The next transformation of the Genmab story could be the development of Arzerra for multiple sclerosis and new antibody-based cancer treatments.

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                  • B Offline
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                    BiotechPro
                    wrote on sidst redigeret af
                    #752

                    CAR: Genmab currently has two projects in early clinical development (tisotumab vedotin and HuMax-AXL-ADX) and has said that two more projects from its pre-clinical pipeline will advance to the clinic in H2(17).

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                    • B Offline
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                      BiotechPro
                      wrote on sidst redigeret af
                      #753

                      CAR: Based on our estimates the current share price fully discounts our base case SOTP valuation. Our bull case shows potential upside to DKK2,572 per share, primarily driven by new indications beyond multiple myeloma, particularly solid tumours. However, we find the risk/reward asymmetrical. Our bear case points to DKK858 per share.

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                      • B Offline
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                        BiotechPro
                        wrote on sidst redigeret af
                        #754

                        CAR: The next important data point is likely to be announced in Q3(17) when the interim analysis of the ALCYONE trial (Da-VMP versus VMP in patients ineligible for autologous stem cell therapy) is expected.

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                        • B Offline
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                          BiotechPro
                          wrote on sidst redigeret af
                          #755

                          CAR: The ALCYONE trial I is the first of three phase III trials of Darzalex in first line multiple myeloma to report data. Our current probability of success for Darzalex in first line multiple myeloma is 85%. If we increase it to 100%, Darzalex NPV increases by DKK102 per share.

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                          • F Offline
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                            flottenschmecker
                            wrote on sidst redigeret af
                            #756

                            Tak for det BiotechPro. Ud fra dine kommentarer ligner det mest en "ikke-analyse" fra Carnegies side. Vi tror ikke en skid på Gen ud over dara...

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                            • F Offline
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                              flottenschmecker
                              wrote on sidst redigeret af
                              #757

                              Deres seneste analyse var ikke synderligt tynget af indsigt eller viden. Den her analyse ser også ud til at man bruger "obligationsmodellen" til at estimere pengestrømmen...

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                              • Legolas23L Offline
                                Legolas23L Offline
                                Legolas23
                                wrote on sidst redigeret af
                                #758

                                En endelig godkendelse for ALCYONE vil udløse 102 kr og være lig med de sidste 15% i analysen. Når man ved patientgrunflaget bliver fordoblet i 1. Linie er det også lavt og ikke realistisk sat.

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                                • F Offline
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                                  flottenschmecker
                                  wrote on sidst redigeret af
                                  #759

                                  Det er lige det. Seler og livrem analyser i biotek er i bedste fald ubrugelige

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                                  • nohopeN Offline
                                    nohopeN Offline
                                    nohope
                                    wrote on sidst redigeret af
                                    #760

                                    Hvad sker der med patientgrundlaget i 2. og efterfølgende linier når Dara bliver taget i brug i 1. linie ?

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                                    • G Offline
                                      G Offline
                                      GeorgeBest
                                      wrote on sidst redigeret af
                                      #761

                                      Man vel forestille sig at for de patienter der ikke får dara I 1. linie, vil få det I anden linie, når første behandling ikke mere virker

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                                      • nohopeN Offline
                                        nohopeN Offline
                                        nohope
                                        wrote on sidst redigeret af
                                        #762

                                        Man kunne også forestille sig at 2. linie ville blive mindsket.....

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                                        • F Offline
                                          F Offline
                                          flottenschmecker
                                          wrote on sidst redigeret af
                                          #763

                                          SC dara maintenance, darkombo med andre medikamenter og så kan dara nok alligevel ikke forvente 100pct penetration i 1st line

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