Genmab — December 2015
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Er det eneste, jeg kender. https://clinicaltrials.gov/ct2/show/NCT02388048?term=ofatumumab+%26+ibrutinib&rank=1
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i hvilken indiation?
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det lyder aggressivt - er de eneste data vi har ikke fra det her fase 1/2 safety rr cll combo studie - http://www.bloodjournal.org/content/early/2015/06/30/blood-2014-12-617522?sso-checked=true
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næh - det tror jeg såmænd heller ikke. Men jeg tænker, at det er eneste studie, der berettiger opstart af en fase III
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This study is a Multicentre, Open-label, Phase II study of Daratumumab and Dexamethasone in MM patients. Eligible patients must have a symptomatic RRMM with a measurable disease, resistant or refractory to Bortezomib and Lenalidomide and Pomalidomide.
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sikke en sur dag - C20cap dykker endda under 1.000
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In vivo, ADCT-301 demonstrates dose-dependent antitumor activity against subcutaneous and disseminated lymphoma models. For example, in the Karpas 299 xenograft model, 10/10 tumor-free survivors are observed following a single dose of 0.5 mg/kg, whereas Adcetris
gives only a modest delay in mean tumor growth at 0.5 mg/kg, despite this tumor expressing three-fold higher target antigen levels for this drug.https://ash.confex.com/ash/2015/webprogram/Paper80592.html -
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