Genmab — April 2015
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We revealed that IgG antibodies form hexamers on the cell surface following antigen binding. These hexamers are critical for optimal C1q binding and CDC. IgG hexamerization occurs through specific non-covalent interactions between Fc-segments. We now identified mutations that enhanced IgG clustering after antigen binding to cells which led to an increase in C1q binding and CDC. Our data represent a promising novel approach for improving the efficacy of therapeutic antibodies.
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The DuoBody platform represents a novel and elegant post-production technology for the generation of stable bispecific antibodies. This platform is based on the easy-to-use method of controlled Fab-arm exchange and is used to generate bispecific antibodies that retain the biochemical characteristics and quality attributes of regular IgGs. The process has shown to be robust and scalable from bench (μg-mg) to mini bioreactor (mg-g) and manufacturing (kg) production.
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Tak Gentogen.
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Jeg skriver i Genmabchatten, men min I-pad hakker den over i den forkerte chat nogen gange.
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136.000 stk har anonyme nu nettosolgt. De købte små 200.000 fredag og mandag.
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Enig Solsen. Det ser påfaldende ud.
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525 skulle meget gerne være vendepunktet.
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