Genmab — April 2015

[Helge_LarsenPI-redaktør]

blevet

[Repsac]

De anonyme er vist ikke helt færdige endnu.

[Helge_LarsenPI-redaktør]

Det er det som kan bekymre her intraday.

[Repsac]

så længe du ikke har købt ind for de 5 kr går det nok.

[Helge_LarsenPI-redaktør]

Jeg solgte i 539. Det blev så til 4 kr.:-)

[Helge_LarsenPI-redaktør]

535 er blevet testet to gange nu. Der strømmer pænt med købere til her.

[gentogen]

Janine Schuurman, Ph.D., Vice President, Research, Genmab: Enhanced IgG Hexamerization Mediates Efficient C1q Docking and More Rapid and Substantial Complement-Dependent Cytotoxicity (CDC): Preclinical Proof of Concept.

[gentogen]

We revealed that IgG antibodies form hexamers on the cell surface following antigen binding. These hexamers are critical for optimal C1q binding and CDC. IgG hexamerization occurs through specific non-covalent interactions between Fc-segments. We now identified mutations that enhanced IgG clustering after antigen binding to cells which led to an increase in C1q binding and CDC. Our data represent a promising novel approach for improving the efficacy of therapeutic antibodies.

[gentogen]

Engineering Antibodies at PEGS Summit | Protein & Antibody Engineering Summit 2026

PEGS Engineering Antibodies conference offers a forum for discussing new technologies for overcoming complex engineering challenges including membrane-bound targets, agonism, and more.

Pegs Summit (www.pegsummit.com)

[gentogen]

The DuoBody platform represents a novel and elegant post-production technology for the generation of stable bispecific antibodies. This platform is based on the easy-to-use method of controlled Fab-arm exchange and is used to generate bispecific antibodies that retain the biochemical characteristics and quality attributes of regular IgGs. The process has shown to be robust and scalable from bench (μg-mg) to mini bioreactor (mg-g) and manufacturing (kg) production.

[gentogen]

The presentation will highlight recent progress in terms of DuoBody discovery, proof-of-concepts, characterization and development.

[gentogen]

Object moved

(www.pegsummit.com)

[celsius]

tusind tak Gentogen, du forstår som altid at bringe lys i mørket -:) .. og igen det blir en fantastisk måned maj 2015 .. pyha !!

[celsius]

det gælder om at holde på hat og briller .. det er blir nok den mest afgørende måned Genmabs´historie og går det godt så sør tør jeg slet ikke tænke på hvor kursen ender bare i år 2015

[Helge_LarsenPI-redaktør]

Tak Gentogen.

[celsius]

Helge husk at skrive Genmab chatten -:) men ellers har du ret og tager det
skam heller ikke særlig tungt !

[Helge_LarsenPI-redaktør]

Jeg skriver i Genmabchatten, men min I-pad hakker den over i den forkerte chat nogen gange.

[celsius]

jeg víl hverken eje eller ha´en I-pad .. elsker min bærbar dell notebook Windows 7 .. det fås ikke bedre og det virker -:)

[Helge_LarsenPI-redaktør]

136.000 stk har anonyme nu nettosolgt. De købte små 200.000 fredag og mandag.

[JKY_VH]

fra sund fornuft til galimatias:-)