Genmab — Maj 2014
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for 10 mg SAR vs. 16 mg. Dara kunne dara godt ligne vinderen. Men kan de hæve til 20 mg. uden safety issues kan dara få det svært
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Men lad os nu først se til ASCO. Der kan vi direkte sidde og sammenligne CR og ORR i SAR+Revlimid og Dara+Revlimid
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jeg fandt selv svar. SAR tester også 20 mg. så mon ikke vi får data der til ASCO også
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EMA udsender som regel meeting hoghlights dagen efter mødets sidste dag, så HVIS der er besluttet noget endeligt, er i morgen en mulighed, men highluights omfatter jo ikke alt. Så vidt jeg kan se, så sker det dog tit, at de over flere gange udbeder sig flere oplysninger, så vi får se.
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Hm. Jeg læste det først som kritisk i forhold til Gazyva, men det hedder i ibrutinib studiet: The design of combined treatment schedules with these kinase inhibitors and anti-CD20 antibodies should therefore consider the multiple negative interactions between these two classes of agents.
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men gentogen er det ikke fordi de har testet med Ritxuan og Gazyva. De angriber begge ADCC ligesom Kinaserne og vil nok få negative interactions hvorimod Arzerra's CDC killing vil lave fortærskning til kombinationen
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http://bloodjournal.org/content/123/12/1957?rss=1&variant=short jo det er Ibrutinibs blokering af ADCC, der er problemet
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I har nok ret, men det er skrevet, så jeg ikke helt forstår det http://files.shareholder.com/downloads/AMDA-KPIBN/3189490857x0x757121/F224E13F-4143-4E97-B339-D03AD9E14257/EHA2014-Ofatumumab-Ibrutinib-Prelinical-DaRoit.pdf
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Genmab har lagt alle abstracts på hjemmesiden nu http://ir.genmab.com/downloads.cfm
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The combination of ibrutinib with type II CD20 mAbs does not lead to enhanced direct
cytotoxicity in vitro. In contrast, it inhibits all cell-mediated cytotoxic mechanisms of action of CD20 antibodies and
has minor effects on CDC. Idelalisib has similar, albeit weaker, inhibitory activity on the cell-mediated effector
mechanisms of CD20 mAbs. The design of combined treatment schedules with these kinase inhibitors and anti-
CD20 antibodies should therefore consider the multiple negative interacti
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