Genmab — November 2013
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J&J får hurtig FDA-godkendelse
FDA har godkendt et lægemiddel fra Johnson & Johnson til behandling af lymfekræft efter en ualmindelig kort evalueringsperiode på blot fire måneder. Det er blot anden gang, at et lægemiddel bliver godkendt under FDAs specielle Breakthrough-program.
(medwatch.dk)
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Ibrutinib sælges for 20$ pr. pille
det svarer til 130.000$ om året pr. patient i Mantle cell så vidt jeg kan se !!! 
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the agency's accelerated approval program, which allows the FDA to approve a drug to treat a serious disease based on clinical data showing that the drug has an effect on a surrogate endpoint that is reasonably likely to predict a clinical benefit to patients
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Among the 19 patients evaluable for response, overall response rate was 94%, with CR in 17 patients, partial remission in one patient and progressive disease after the second cycle in one patient; 15 out of 15 patients evaluable for minimal residual disease in the BM showed molecular remission.
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Godt at Arzerra kun jagter R/R DLBLC label, for SPectrums nye stof Marqibo deler satme tæsk ud i frontline DLBLC. TJek lige de har 10 years follow up data: https://ash.confex.com/ash/2013/webprogram/Paper55944.html
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ja nemlig. i CHOP behandling består O jo af Vincristine. Det SPPI vil er at udskifte Vincristine med deres Liposome formulation af Vincristine kaldet marqibo og derfor lave R-CHMP (Eller A-CHMP med arzerra) istedet for CHOP fordi de beviser at Marqibo er langt stærkere end normal vincristine
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men jeg syntes alligevel det er vanvittige resultater at få ved at skifte fra normal vincristine til marqibo. Den liposome formulation giver godt nok gas.
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Iøvrigt tester SPPI jo også Zevalin i phase III i frontline DLBLC med Z-CHOP. Men igen, det er heller ikke konkurrent til Arzerra da de jo jagter Rituxan R/R DLBLC patienter
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