Genmab — Maj 2021

[Bulder]

I glofi-abstractet opererer man med komplet metabolisk respons. I epco bruger man komplet respons. Jeg er ikke lykkedes med at finde en forklaring på forskellen. Nogen?

[peter12]

Google siger https://bmccancer.biomedcentral.com/articles/10.1186/s12885-018-4687-9

[Helge_LarsenPI-redaktør]

Aktier/middag: Rekord i C25 og fem
eliteaktier https://www.proinvestor.com/investornyt/675294/aktier-middag-rekord-i-c25-og-fem-eliteaktier

[Bulder]

Peter, hvordan udleder du af artiklen, hvad forskellen er?

[E_L]

could it be that CMR is according to PET scan, and
CR is CT scan, but i am not sure on this

[Bulder]

Could be. They say PET every time they say CMR. Is the one more reliable than the other?

[Raun]

TA kyndige?..... Hvis jeg har forstået det korrekt, har Genmab igennem det seneste stykke tid, været i teknisk nedtrend..... Hvis aktien holder sit nuværende niveau resten af dagen og forhåbentlig også mandag. - Vil aktien da ikke være inde i sin stigende trendkanal igen?

[E_L]

yes, PET is more reliable

[E_L]

CT Scan vs. PET Scan - Health Images

CT and PET scans are both diagnostic imaging scans used by doctors. Learn about the similarities and differences between these two scans here.

Health Images (www.healthimages.com)

[Bulder]

But it sounds like PET is used for cancer, so why CT?

[Bulder]

And CT is x-ray. Can x-ray detect cancer in liquids?

[E_L]

i am not sure; it probably has to do with how the trials are set up; CT scan is probably a lower entry bar, that does not necessarily mean these patients did not get PET in most of the hospitals

[E_L]

For example, if you look at Main Inclusion Criteria Escalation Part for Epco Ph I/II trial, it says '
Patients must have measurable disease by CT, MRI or PET-CT scan'

[E_L]

In the Ph3 it already says 'Patients must have detectable disease by PET scan and measurable by CT scan or MRI'

[Bulder]

so detectable vs measurable?

[E_L]

you can rest assured that response rate classification is very strict and will be checked stringently by authorities

[E_L]

they have strict criteria for it in the Ph3 ' Response is determined by the Lugano criteria and LYRIC'

[Bulder]

Yes, I assume that CR vs CMR is of minor importance then.

[E_L]

my gutfeel is that most epco response also are CMR, but if not ALL of them are, or if the trial criteria were not CMR they can not call it that

[E_L]

disclaimer; i am NOT a doctor