Genmab — November 2020

[GeorgeBest]

But I am sure they will deliver again

[AaBforever]

@E L What do you expect we will hear on fridag 13.?

[GeorgeBest]

Jan always points out Genmabs abilities to combine bispecific antibodies via robotics. Any idea why other Pharma companies can‘t copy?

[GeorgeBest]

He says they can produce thousands of samples in the same time as competitors produce a handful!

[Bulder]

Hopefully an assessment of the quality of efficacy. That's where I'm a little sceptic maybe. But we'll also soon see assessments from the medical world. Looking forward to that.

[Bulder]

I'm not worried of safety at all.

[gdn55]

Måske derfor man skal beholde Genmab, eller købe inden de bliver købt

[E_L]

yes, maybe. but i don't expect new data @AaBforever , more of a deep dive into what we know and more explanation

[E_L]

regarding safety Bulder , is that based on the data
we just saw?

[E_L]

because before, i was worried about liver tox

[E_L]

and it seems
manageable

[GeorgeBest]

Nordea think the liver side-effects may hinder going to high doses!

[E_L]

that would make sense. maybe that is something we can hear about on friday. But from the data we saw today, i found it hard to find a strong correlation between dose and efficacy

[E_L]

or dose and toxicity for that matter, we saw no data on that i think

[Bulder]

It's based on the conclusion in the abstract

[E_L]

and you can be sure Genmab does know that data

[E_L]

yes, ok, me too

[Bulder]

didn't winkel comment on the liver-issue recently? or was that dr5/dr5?

[E_L]

"29/3 09:33
af Sukkeralf
The problem with 4-1BB was liver tox if I remember what Jan said at some point - so with these new attempts where you only get them attivated in the microenviroment of the solid tumours it should avoid liver tox"

[E_L]

i think he also asked Jan in a QA about dr5 / liver tox, but Jan didnt really answer