Genmab — Oktober 2020
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Egentlig ikke en nyhed, men faldt over denne: Daratumumab potentiates the antitumor activity of CHOP and R-CHOP in MCL and FL xenografts. Furthermore, in a patient-derived DLBCL xenograft model, daratumumab anti-tumor activity was comparable to R-CHOP and the addition of daratumumab to either CHOP or R-CHOP led to full tumor regression.
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our findings warrant further clinical development of daratumumab in NHL providing a strong rationale for examining its clinical efficacy in different scenarios, including maintenance therapy after induction therapy, cases with anti-CD20 resistance, FL histologic transformation, and as frontline in combination with the standard of care (CHOP/ R-CHOP)
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Tusinde tak for info GTG.
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Nåja, sà skal dara konkurrere med epco
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Selvfølgelig
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Men bortset fra det, så blev dara jo klinisk testet i NHL for år tilbage med skuffelse til følge. Tvivler på, det bliver taget op igen. https://www.mdedge.com/hematology-oncology/article/194227/mantle-cell-lymphoma/daratumumab-disappoints-non-hodgkin-lymphoma
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