Genmab — Oktober 2020
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12:40 I like the phrase “superior”
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Conclusions DuoBody-PD-L1×4-1BB demonstrated biologic activity and a manageable safety profile. Encouraging early clinical activity across different dose levels was observed in a heavily pretreated population with advanced solid tumors, including those resistant to prior immunotherapy or typically less sensitive to ICIs. Expansion cohorts of patients for whom DuoBody-PD-L1×4-1BB treatment could be relevant and biologically sound have started enrollment. Updated data will be presented.
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SITC ID: 704
Preclinical mechanism of action and pharmacodynamic biomarker studies of DuoBody
-CD3x5T4 in vitro and in vivo in solid cancer models https://sitc.planion.com/Web.User/AbstractDet?ACCOUNT=SITC&ABSID=13592&CONF=SITC20&ssoOverride=OFF&CKEY= -
Opdaterede salgstal på Darzalex. https://www.proinvestor.com/boards/87573#87574
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SITC ID: 617
Tisotumab vedotin shows immunomodulatory activity through induction of immunogenic cell death https://sitc.planion.com/Web.User/AbstractDet?ACCOUNT=SITC&ABSID=13984&CONF=SITC20&ssoOverride=OFF&CKEY= -
SITC ID: 621
A Tregs depleting, CD25-targeted antibody-drug conjugate synergizes with tumor-targeted radiotherapy and systemic interleukin-2 in pre-clinical models of solid cancers https://sitc.planion.com/Web.User/AbstractDet?ACCOUNT=SITC&ABSID=13536&CONF=SITC20&ssoOverride=OFF&CKEY= (camidanlumab tesirine (ADCT-301)) -
Tak Helge. Projekteret i den øveste del af intervallet. Hvis det ender sådan, så kan vi ikke klage
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TEPEZZA
(teprotumumab-trbw) Data from the Phase 2 Clinical Trial Evaluate Longer-Term Responses in People Living with Thyroid Eye Disease (TED)
10/14/20 https://ir.horizontherapeutics.com/news-releases/news-release-details/tepezzar-teprotumumab-trbw-data-phase-2-clinical-trial-evaluate -
Yes, i am also really curious. The good thing is that Genmab can choose from strength. If they choose not to pursue it, it will not be such a big deal, as they have plenty of other stuff in their pipeline, probably more than they can handle at the moment. So we know that if they do choose to pursue it, we can be reasonably optimistic it can be successfull
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"Our collaboration and license agreement with Genmab may require a divestment of Cami, in which Genmab has a 25% interest. On June 24, 2020, we and Genmab agreed to enter into a period of good faith negotiations regarding the key financial terms of our license agreement."
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Aftalen skal i hvert fald laves signifikant om hvis Genmab skal smide flere penge efter stoffet. Jeg hælder til Genmab smider de 25%. Mod et lille upfront beløb og så måske 10-25% af ADC fremtidige potentielle royalties. Der skal alligevel en big pharma med ind over for at marekdesføre
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