Genmab — Juni 2020

[Bulder]

The TIL therapy under investigation in this clinical trial (LN-145) is derived through isolation of a patient’s own naturally occurring TIL from a sample of cancerous tumor removed from the patient. After TIL are extracted from the tumor, they are multiplied in a laboratory until billions of TIL are obtained. https://www.iovance.com/clinical/c-145-04-cervical-carcinoma/

[GeorgeBest]

Yes sounds similar to CAR-T

[E_L]

24/1 18:05
af E L

Upcoming events – Genmab's route to market,... on TV - (link)

[E_L]

ah that link doesn't work like that ,
try https://www.evaluate.com/vantage/articles/events/upcoming-events/upcoming-events-genmabs-route-market-and-late-stage-data

[Don_Joning]

ifølge bussiness wire vil markedet for livmoderhalskræft ramme i nærheden af 17,9 milliarder dollar i 2022, hvis vi antager at Tiso kommer i første eller 2. linje er der nogen der har et forsigtigt bud på hvor mange procent af den kage man vil kunne få anddel i
? https://www.businesswire.com/news/home/20191211005568/en/Global-Cervical-Cancer-Drugs-Market-Report-2020

[Sukkeralf]

I E L´s link hedder det 240-600 millioner dollars i 2. linie - i første linie kræver det data før man kan vurdere dette.

[Don_Joning]

en helt anden ting, hold op hvor er det dejligt, at der kommer nye behandlinger indenfor dette område, skrækkelig sygdom med katastrofale konsekvenser for alt for mange unge kvinder

[Don_Joning]

ok tak Sukkeralf

[nohope]

Livmoderhalskræft er vel en sygdom så vi vil se forsvinde over den kommende tid. Den kan vaccineres væk. At der er tåber der heller ser deres døtre dø af livmoderhalskræft end få et stik slipper vel op.

[Bulder]

Ja, det er det der er spørgsmålet. I Australien regner man med om få år at have udryddet lmhk, fordi tilslutningen til vacc-programmet er 100%. I Japan derimod er det tæt på 0%.

[Bulder]

I DK er stemningen vel ved at vende til fordel for vacc. I US er det bob bob. Så der vil gå en årrække med et marked for lmhk-terapier.

[Bulder]

Og til den tid har TV måske vist sig effektiv i en række andre solide tumorer.

[E_L]

it will still take some time for this to disappear, have another look at the Cervical Cancer Market Size, p35 June investor prestentation, shocking how many
still die in Europe https://ir.genmab.com/download-library#content

[E_L]

I posted this seekingalpha article a while ago, as it also looked at cervical cancer https://seekingalpha.com/article/4335715-agenus-time-of-coronavirus

[Bulder]

Yes I was quite surprised on European numbers. What countries are they that bring the numbers so high?

[E_L]

don't know, good question. I know in the netherlands it is only 200 -250, we have large cervical cancer screening programmes

[E_L]

HPV Vaccination here is around 70% i believe, by chance it was in the newspaper that this year it went up by 7%

[E_L]

this morning

[nohope]

When will it be available for commercial use ? In 5-10 years ? At that time we hopefully(!) will see a sharp decline in cervical cancer due to vaccine.

[GeorgeBest]

Tiso will be available next year in 2nd line and onwards