Genmab — November 2019

[Bulder]

Isa + atezo i kolorektal har måske data til næste år. Isa + atezo i Advanced Malignancies startede først sidste år, så der går en rum tid endnu inden data. Begge er fase 2. https://www.clinicaltrials.gov/ct2/results?cond=&term=isatuximab+atezolizumab&cntry=&state=&city=&dist=

[Sukkeralf]

Problemet med denne passive tilgang er, at skulle Sanofi begynder at se positive resultater, så kan du være sikker på de holder kortene tæt til kroppen længst muligt, sålænge de fornemmer at Janssen ikke har gang i noget. Dermed ender man med at være relativt langt bagefter.

[Sukkeralf]

Forstår dog godt at man vil have sc dosering i mål før man kaster sig over usikre studier i solide tumorer, hvor man i værste tilfald pludselig måske står med nogle dødsfald der kan kaste smuds over sc dara

[E_L]

agree. and JNJ clearly stated that they would wait with solid until the SC approval, that part is not new.

[E_L]

(why is Jan talking in the quiet period by the way??)

[Sukkeralf]

Probably just talking gibberish

[E_L]

thinking out-loud; given your concern on damaging the MM franchise with Dara solid trial; could they wait for HexaBody-CD38 and try it with that..?

[Sukkeralf]

Yes and no for you could end up the same way that deaths in a solid trial could jepardize the LCM in MM

[Bulder]

From the press announcement: "Next-generation HexaBody-CD38 could potentially add to the DARZALEX multiple myeloma franchise and expand the potential of CD38-targeted therapies in further indications" - could be solids

[Helge_LarsenPI-redaktør]

Kære venner. Jeg mangler i den grad spørgsmål til Q&A. Håber at de kommer hurtigst muligt.

[Bulder]

You had a Q at 10:41 E L

[E_L]

well ok then, i already asked when he expects to start the first trial, i'll also ask if he thinks it will make for a better option with solids

[Sukkeralf]

Vi skulle da også gerne snart se en IND/CTA for DuoHexa-CD37

[E_L]

maybe it is already in the report tomorrow, we have seen that before, they don't always do a separate press release

[Sukkeralf]

Agree - but that would be nice

[Solsen]

Vi skal nok levere spørgsmål Helge

[Sukkeralf]

Nogen forventninger til ASH abstracts i morgen:

[Sukkeralf]

https://www.hematology.org/Annual-Meeting/Abstracts/

[bibob]

Nok ikke så høje i år.

[Helge_LarsenPI-redaktør]

Tusinde tak Solsen. Jeg har Oncology i morgen, Genmab på Fredag og Zealand sener på måneden. Det trækker tænder ud i en allerede juletravl tid i produktion, grossist- og detailbranchen.