Genmab — November 2019
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En analysevideo til at fordrive ventetiden med: https://www.proinvestor.com/debat/78861
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ash: Conclusions: Subcutaneously administered GEN3013, a potent CD3×CD20 bsAb, shows good tolerability and early evidence of clinical activity at low dose levels in heavily pretreated pts with relapsed or refractory B-NHL. All CRS events were non-severe and did not lead to discontinuation. No DLTs were observed. Dose escalation is ongoing; updated data will be presented. Dose expansion will begin upon determining the recommended Phase 2 dose (RP2D) (NCT03625037).
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758 First-in-Human, Phase 1/2 Trial to Assess the Safety and Clinical Activity of Subcutaneous GEN3013 (DuoBody
-CD3×CD20) in B-Cell Non-Hodgkin Lymphomas https://ash.confex.com/ash/2019/webprogram/Paper121460.html -
4066 Duobody-CD3xCD20 Induces Potent Anti-Tumor Activity in Malignant Lymph Node B Cells from Patients with DLBCL, FL and MCL Ex Vivo, Irrespective of Prior Treatment with CD20 Monoclonal Antibodies https://ash.confex.com/ash/2019/webprogram/Paper125765.html
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Mim8 utilized the Duobody
platform / Novo Nordisk / hemophilia A https://ash.confex.com/ash/2019/webprogram/Paper122817.html
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