Genmab — August 2019

E_L

no, I don´t think that is what they are trying to imply, but it is clear that those are competition. It is still early days for EnaV; the data will have to prove its value. It is a good sign for now that it is being included in these conferences

Plimsoller

Ok. Thank you.

Bulder

Bergenbio's treatment is a combo. EnaV is mono and has not yet been tested in combination. Still too early to say. Maybe a comment from Sukker on this issue?

GeorgeBest

BerginBio is second line. EnaV is 4th plus lines. Therefore the EnaV patients are much more sick.

Bulder

Thx GB. I was not sure about that. Where did you find that info?

GeorgeBest

Bulder: can you read Nordea comments from 22 August?

Solsen

In the announcement they mentioned 4 lines or less

GeorgeBest

Nordea write: patients had failed 4 or more prior lines of therapy including platinum based chemo

Solsen

Makes a difference - perhaps Iam wrong

GeorgeBest

So infact EnaV is 5th line...

Solsen

who had failed ≤4 prior lines of therapy - right

Solsen

https://wclc2019.iaslc.org/wp-content/uploads/2019/08/WCLC2019-Abstract-Book_web-friendly.pdf pp 217-218

Solsen

Difficult comparison to Bergenbios compound.

Bulder

patients with stage III/IV
NSCLC without sensitizing EGFR mutations (EGFR WT) or ALK
rearrangements (ALK-
) who had failed ≤4 prior lines of therapy, så nogle har haft færre end 4 behandlinger.

Bulder

Bergenbio: Cohort A will consist of patients who received a maximum of 1 prior line of platinum-containing chemotherapy and no prior immunotherapy of any kind. Cohort B will consist of patients with a maximum of 2 prior lines whereas the most recent line must have included a PD-(L)1 inhibitor.

nohope

Er det egentlig ikke et lidt underligt kriterium ? Mindre end 4 - så kan det være 0-1-2-3-4 ? Det ville være mere logisk hvis det hed 4 eller flere ?

Bulder

Det betyder op til og med 4. linje.

Bulder

... eller ned om man vil

nohope

Det er jeg med på, men synes stadig det er underligt kriterium.

nohope

Når du eksperimenterer så plejer du at få dem der opgivet?