Genmab — Juni 2019

[Sukkeralf]

And the same holds actually for the CD3xCD20 bispecific program. There's considerable excitement now in the hematology field because of the Regeneron and Roche programs. Yesterday, the Regeneron program created some lesser excitement because of some fatalities apparently in one of their trials. But we have a very different molecule, which preclinically seems to be at least 100-fold more potent than the Regeneron CD3xCD20 and 2 to fourfold more potent preclinically than the best Roche program. So

[Sukkeralf]

We expect data for the CD3xCD20 before or at the ASH meeting this year. So I think it's heating up quite well, Sachin. And I think we could potentially see partnerships for both of these programs to maximize the potential for the CD3xCD20, the very competitive hematological area. Now a little bit behind Roche and Regeneron but with a very differentiated molecule. This is given subcutaneously and preclinically. It's very, very much more potent than these other programs, and we use a different way

[Sukkeralf]

of silencing the bispecific. So we expect potentially less side effect issues than had been seen with this earlier generation, more primitive bispecific. So yes, that's probably all I can say at this moment.

[Sukkeralf]

As DR5/DR5 is more mature than CD20/CD3 its sounds like this is the one Genmab has in mind to partner up first

[Sukkeralf]

unless they can get a good broad deal - and I dont think it would be Roche

[Sukkeralf]

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(www.fiercebiotech.com)

[Sukkeralf]

What about Sanofi - perhaps they could settle for Eu and RoW

[E_L]

@Plimsoller ? i don't know? you have holiday on monday... (again...)

[Plimsoller]

@E L Yes Sir

[E_L]

you don't have to wait that long for that ; tomorrow is closed also?

[Plimsoller]

You are right that the stock exchange is closed tomorrow - most people are however working.

[E_L]

OMG horrible... i feel sorry for you

[Plimsoller]

Me too. I only have half a day off

[Solsen]

Jeg tager mig en omsorgsdag og passer konen godt

[Solsen]

We have holidays, days off when your child are sick, days to look after family. Denmark is fantastic

[Sukkeralf]

Celgene viser kliniske data for arvtager til super-blockbuster mod knoglemarvskræft

Amerikanske Celgene har fremlagt positive kliniske data for et nyt immunmodulerende middel til behandling af knoglemarvskræft, som ser ud til at kunne hjælpe patienter, når behandling med Genmabs Darzalex eller selskabets egen storsællert Revlimid fejler.

(medwatch.dk)

[bibob]

Bella1. 10.47 - Kan man ikke kun bruge de samme kaffebønner 1 gang ???

[E_L]

@Sukkeralf are they talking about Iberdomide there?

[Bella1]

Det skal nok komme. Foreløbig vil jeg lægge mig en time på hver side, og vente på miraklet.....

[Bella1]

• og bagefter er der mirakelkaffe!