Genmab — Maj 2019

[E_L]

2/5 10:19
af E L
Usmani - Daratumumab as Frontline Treatment for Multiple Myeloma - https://www.youtube.com/playlist?list=PLZRBUfZtYYA9r0cx7Qo2psrJ9wi2sJg7A

[E_L]

2/5 12:35
af E L
Do I understand this correct, from Usmani video 3, that the Lenalidomide dosing in the experimental arm turned out to be 76% of the dosing of the standard care arm

[E_L]

Ola Landgren, M.D.
@DrOlaLandgren

https://twitter.com/DrOlaLandgren/status/1129544139215912960

[E_L]

Clinical efficacy of daratumumab, pomalidomide, and dexamethasone in patients with relapsed or refractory myeloma: Utility of re‐treatment with daratumumab among refractory patients https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32178

[E_L]

A Multiple Myeloma Roundtable: Treatment Trends and Recent Clinical Advances http://obroncology.com/article/a-multiple-myeloma-roundtable-treatment-trends-and-recent-clinical-advances/#

[Bulder]

Yes, they have reduced dose of len more frequently in the exp-arm than in soc-arm. They have also done this earlier with pom. At least in the first cycle or two. I suppose it is due to side effects.

[Helge_LarsenPI-redaktør]

Lad os endelig for mere af dette her: http://www.proinvestor.com/investornyt/617848/her-er-ugens-vindere-og-tabere-alk-netcompany-og-genmab-topper

[Bulder]

What does Plesner mean by: ... "but the results may be further improved"?

[E_L]

Autologous Stem Cell Transplantation Challenged by Emerging Pharmacotherapies in Multiple Myeloma https://www.hematologyadvisor.com/home/topics/myeloma/evaluating-the-viability-of-pharmacotherapies-as-an-alternative-to-transplant-in-multiple-myeloma/

[E_L]

yea, read that too... maybe improved OS or HR?

[Bulder]

Landgren's statement is interesting: "No IRRs. Minimal or no steroids/premeds." That could be the reason for dara's recurrence in solids.

[E_L]

good point. that could be the key if we think about the JNJ presentation, where they said that " they are developping a 'steroid sparing regimen' to be used with Dara and they indeed needed SC to do that"

[Bulder]

A chairman of a patient organization once said that if only pts could avoid dex, that could save marriages. Dex is extremely unpopopular and considered the worst of the drugs. So sc dara with no or minimal dex will be requested by pts (and their relatives).

[E_L]

prednison is already horrible, dex apparantly 5x stronger

[Helge_LarsenPI-redaktør]

God morgen.

[rex_pacis]

God morgen

[transalp]

Go morgen..

[polle1]

God morgen og god dag

[bibob]

God morgen fra solrige Torremolinos.

[Sukkeralf]

Andrew skriver at CD40*4-1BB stadig er on track - de har fjernet den fra clinical trials og der er indsendt en CTA. Så den skal vel dermed i første omgang blot køre i Europa.