Genmab — Maj 2019
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Speaking on Regeneron's quarterly earnings call, CSO George Yancopoulos disclosed two patient deaths in the company's Phase I study combining its in-house PD-1 antibody Libtayo (cemiplimab, formerly known as RG2810) with bispecific antibody RG1979.
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ancopoulos told analysts that "we observed enhanced cytokine release syndrome, or CRS … including unfortunately two fatalities potentially related to the CRS." He added that "we plan to modify the dosing regimen with the goal of minimising toxicity while potentially capturing the potentially increased activity."
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Tak for alle dine skriverier Sukker. Hvis vi er heldige så gør færre bivirkninger forskellen for Genmab CD3xCD20. Silenced FC region og SC. Når jeg siger heldige så indrømmer Genmab selv der er uforudsigeligt hvad der sker: http://www.bloodjournal.org/content/132/Suppl_1/1664
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"This unique cytotoxic activity could not be explained by expression levels of the target antigen, nor by the binding affinity or epitope of the B-cell specific Fab arm. This illustrates the complexity of factors that determine the potency of CD3 bsAbs."
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@sukkeralf. Nej kursmæssigt har sc ikke rykket noget (endnu). Men det har de andre studie-nyheder heller ikke siden efteråret. Det eneste, der reelt har kunnet mærkes på kursen var 3-mia-guidningen. Alt andet har været den ene lange næse efter den anden. Belært heraf forventer jeg mig heller ikke noget af Maia-godkendelse - kun te og kiks.
Tak for fin opsummering/gennemgang af GENs situation pt. samt nye stoffer/potentialer.
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