Genmab — Maj 2019
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Tak for sammenfatningen sukker. mht partneraftale (fra CC): "So we have a lot of potential for that program for partnering. We think we want to see data. We expect data for the CD3xCD20 before or at the ASH meeting this year." Så det bliver næppe før sidst på året, at vi ser noget på den front.
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Speaking on Regeneron's quarterly earnings call, CSO George Yancopoulos disclosed two patient deaths in the company's Phase I study combining its in-house PD-1 antibody Libtayo (cemiplimab, formerly known as RG2810) with bispecific antibody RG1979.
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ancopoulos told analysts that "we observed enhanced cytokine release syndrome, or CRS … including unfortunately two fatalities potentially related to the CRS." He added that "we plan to modify the dosing regimen with the goal of minimising toxicity while potentially capturing the potentially increased activity."
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Tak for alle dine skriverier Sukker. Hvis vi er heldige så gør færre bivirkninger forskellen for Genmab CD3xCD20. Silenced FC region og SC. Når jeg siger heldige så indrømmer Genmab selv der er uforudsigeligt hvad der sker: http://www.bloodjournal.org/content/132/Suppl_1/1664
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"This unique cytotoxic activity could not be explained by expression levels of the target antigen, nor by the binding affinity or epitope of the B-cell specific Fab arm. This illustrates the complexity of factors that determine the potency of CD3 bsAbs."
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