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Genmab — Marts 2019

Planlagt Fastgjort Låst Flyttet Genmab
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  • E Offline
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    E_L
    wrote on sidst redigeret af
    #986

    from recent Conference, Tisotumab vedotin
    https://www.mdedge.com/hematology-oncology/article/197472/gynecologic-cancer/tisotumab-vedotin-shows-promise-recurrent

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    • P Offline
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      polle1
      wrote on sidst redigeret af
      #987

      Godmorgen og god dag

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      • B Offline
        B Offline
        bibob
        wrote on sidst redigeret af
        #988

        @pensionisten. Jeg håber at din kone må få nye og bedre behandlingsmuligheder. Der kommer heldigvis nye og forhåbentlig bedre medicin på markedet. Held og lykke. 🙂

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        • J Offline
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          JKY_VH
          wrote on sidst redigeret af
          #989

          Også H&L herfra og god morgen:-)

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          • BulderB Offline
            BulderB Offline
            Bulder
            wrote on sidst redigeret af
            #990

            8:28: det var så lidt. og held og lykke

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            • E Offline
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              E_L
              wrote on sidst redigeret af
              #991

              and europe
              https://www.globenewswire.com/news-release/2019/03/27/1773690/0/en/Genmab-Announces-European-Regulatory-Submission-for-Daratumumab-in-Combination-with-Bortezomib-Thalidomide-and-Dexamethasone-in-Frontline-Multiple-Myeloma.html?culture=fr-ca

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              • E Offline
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                E_L
                wrote on sidst redigeret af
                #992

                they are on a roll!

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                • S Offline
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                  Sukkeralf
                  wrote on sidst redigeret af
                  #993

                  Nu nærmer ASCO sig snart - ikke at det bliver den vigtigste konference for Genmab, men om ikke andet kommer der vel opdateringer på diverse dara-studier. Abstract deadlines:

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                  • S Offline
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                    Sukkeralf
                    wrote on sidst redigeret af
                    #994

                    ASCO Meetings

                    ASCO Meetings Program Guide

                    favicon

                    (meetings.asco.org)

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                    • S Offline
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                      Sukkeralf
                      wrote on sidst redigeret af
                      #995

                      Nice E L - did we get 100% sure on filing for sc dosing. Was the Columba data enough or.......?

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                      • E Offline
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                        E_L
                        wrote on sidst redigeret af
                        #996

                        that's the million dollar question @Sukkeralf … well more like billion dollar question in this case lol

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                        • S Offline
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                          Sukkeralf
                          wrote on sidst redigeret af
                          #997

                          Bulders question: Can data from the Columba study be the basis for approval in all treatment lines in MM, or do we have to await the sc combo study MMY2040?

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                          • B Offline
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                            bibob
                            wrote on sidst redigeret af
                            #998

                            https://ir.genmab.com/news-releases/news-release-details/genmab-announces-european-regulatory-submission-daratumumab-3

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                            • S Offline
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                              Sukkeralf
                              wrote on sidst redigeret af
                              #999

                              jans answer: The COLUMBA study is the only non inferiority PHIII that would be needed to obtain a label for SC daratumumab...

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                              • S Offline
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                                Sukkeralf
                                wrote on sidst redigeret af
                                #1000

                                In order to obtain a broader label, we would also need to obtain safety data from the PLEIADES study which is evaluating 3 cohorts of patients DARA + RD, DARA + VMP and DARA + VRD. If this study reads out positively, we expect to obtain a broad label for SC DARA..

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                                • S Offline
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                                  Sukkeralf
                                  wrote on sidst redigeret af
                                  #1001

                                  To me thats sounds like they will file first on the Columba data............and then later a sBLA on combination data

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                                  • E Offline
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                                    E_L
                                    wrote on sidst redigeret af
                                    #1002

                                    that is also my best geuss at the moment

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                                    • BulderB Offline
                                      BulderB Offline
                                      Bulder
                                      wrote on sidst redigeret af
                                      #1003

                                      Yes,and with a label limited to R/R MM and not frontline.

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                                      • S Offline
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                                        Sukkeralf
                                        wrote on sidst redigeret af
                                        #1004

                                        yes and maybe maintenance

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                                        • D Offline
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                                          Doc4
                                          wrote on sidst redigeret af
                                          #1005

                                          @pensionisten 8:28....FYI Mayzent = Siponimod og er beskrevet her: https://scleroseforeningen.dk/nyheder/gilenya-20. Samme virkning da siponimod er en syntetisk udgave af Gilenya, som har væet på markedet i 7 år. Siponimod har en bedre bivirkningsprofil, da target kun er 2 ud af 5 forskellige SiP molekyler, hvor Gilenya targets 4/5, hvoraf et i hjertet. Held og lykke;)

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