Genmab — Februar 2019
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Responses lasted an average of 5.7 months, and up to 9.5 months in some patients.
The main side effects reported from the study were nose bleeds, fatigue, nausea and eye problems – but halfway through the trial the researchers adjusted the protocol to reduce these eye-related effects.
TV is made up of a toxic drug attached to the tail end of an antibody. The antibody is designed to seek out a receptor called ‘tissue factor’ – -
present at high levels on the surface of many cancers cells and linked with worse survival. Binding to tissue factor draws the drug inside cancer cells, where it can kill them from within.
The trial initially recruited 27 patients to assess safety and establish the right dose, before expanding to a further 120 patients primarily to look at whether the drug was hitting the right target but also at what effect it had on tumours. -
The majority of patients in the early trial had advanced stage cancer (spread locally or around the body) that had already been treated with, and became resistant to, an average of three different types of treatment.
TV is now being trialled in other cancer types including bowel, pancreatic, squamous cell lung and head and neck, as well as in a phase II trial as a second-line treatment for cervical cancer. -
Kan det ikke være dette ? https://www.clinicaltrials.gov/ct2/show/study/NCT02001623
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God morgen.
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Så kom den også på Lancet Oncology en måned forsinket https://www.thelancet.com/journals/lanonc/onlineFirst
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Dem der kan se potentialet vil nok blive belønnet
Jeg kan anbefale fx at genhøre presentationen fra Jefferies http://wsw.com/webcast/jeff115/gnmfs/ -
mon ikke den bliver grøn nu.. Det må da være nu man skal købe flere.....
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