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Genmab — December 2018

Planlagt Fastgjort Låst Flyttet Genmab
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Denne tråd er blevet slettet. Kun brugere med emne behandlings privilegier kan se den.
  • S Offline
    S Offline
    Sukkeralf
    wrote on sidst redigeret af
    #28

    Jan said Its because Its so hard to predict what you exactly need - three is better than one

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    • S Offline
      S Offline
      Sukkeralf
      wrote on sidst redigeret af
      #29

      But nice data for BsAbs will give more value to Genmabs preclinical and early pipeline as it based on this

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      • SolsenS Offline
        SolsenS Offline
        Solsen
        wrote on sidst redigeret af
        #30

        Discontinuation was relative high in Regenerons trial. The silencing of the CD3 arm could be the right way 😉

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        • BulderB Offline
          BulderB Offline
          Bulder
          wrote on sidst redigeret af
          #31

          Just a detail: It's not the cd3-arm that is silenced. It's the Fc-part.

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          • SolsenS Offline
            SolsenS Offline
            Solsen
            wrote on sidst redigeret af
            #32

            Correct

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            • SolsenS Offline
              SolsenS Offline
              Solsen
              wrote on sidst redigeret af
              #33

              The data presented at ASH included a total of 68 patients with R/R B-NHL who were treated with REGN1979. These patients had received a median of three prior therapies, including an anti-CD20 therapy. As of September 2018, 14 patients had completed treatment, 13 patients remained on treatment and 41 had discontinued treatment. The most common reason for treatment discontinuation was progressive disease (27 patients).

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              • SolsenS Offline
                SolsenS Offline
                Solsen
                wrote on sidst redigeret af
                #34

                2/3 of pts discontinued !

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                • E Offline
                  E Offline
                  E_L
                  wrote on sidst redigeret af
                  #35

                  https://twitter.com/DrOmarNadeem/status/1068937605721448448

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                  • E Offline
                    E Offline
                    E_L
                    wrote on sidst redigeret af
                    #36

                    on Griffin https://twitter.com/akeithstewart/status/1068961191349764096

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                    • P Offline
                      P Offline
                      peter12
                      wrote on sidst redigeret af
                      #37

                      Hvordan kan de skrive 100% ORR når 66% stopper ?

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                      • E Offline
                        E Offline
                        E_L
                        wrote on sidst redigeret af
                        #38

                        JNJ news release https://www.prnewswire.com/news-releases/darzalex-daratumumab-combination-regimens-show-positive-results-for-newly-diagnosed-and-relapsed-patients-with-multiple-myeloma-300758631.html

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                        • SolsenS Offline
                          SolsenS Offline
                          Solsen
                          wrote on sidst redigeret af
                          #39

                          Griffin are outstanding

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                          • SolsenS Offline
                            SolsenS Offline
                            Solsen
                            wrote on sidst redigeret af
                            #40

                            Ny måde at rapportere på peter12. AMG-420 resultater blev rapporteret tilsvarende. Men hvem mon de vil snyde ?

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                            • BulderB Offline
                              BulderB Offline
                              Bulder
                              wrote on sidst redigeret af
                              #41

                              @ peter12: Jeg kan ikke se andet end at pts trods alt responderer, men relapser kort efter alligevel.

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                              • BulderB Offline
                                BulderB Offline
                                Bulder
                                wrote on sidst redigeret af
                                #42

                                HR på pfs i Alcyone faldet fra 0,5 til 0,43!

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                                • SolsenS Offline
                                  SolsenS Offline
                                  Solsen
                                  wrote on sidst redigeret af
                                  #43

                                  Kan du læse det bulder. Synes at sådanne meddelelser er vanvittig dårlige (Regeneron)

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                                  • SolsenS Offline
                                    SolsenS Offline
                                    Solsen
                                    wrote on sidst redigeret af
                                    #44

                                    Super og hvad vi ventede omkring HR.

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                                    • SolsenS Offline
                                      SolsenS Offline
                                      Solsen
                                      wrote on sidst redigeret af
                                      #45

                                      Jeg er ikke sikker på, at de tæller pts med når de "discontinue"

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                                      • P Offline
                                        P Offline
                                        Plimsoller
                                        wrote on sidst redigeret af
                                        #46

                                        Efter den pressemeddelelse, er der overhovedet noget tilbage til præsentationen i morgen?

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                                        • E Offline
                                          E Offline
                                          E_L
                                          wrote on sidst redigeret af
                                          #47

                                          i think so far all looking very good? not seeing any disappointments
                                          ?

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