Genmab — November 2018

Parasitism

God morgen

E_L

and if you are on twitter , have a look at Natalie Callander‏ @nsc_natalie where she talks about a new trial in preparation for Smoldering , Dara + Len/dex, which she hopes to start Feb19

E_L

https://twitter.com/mtmdphd/status/1060287065903034368

E_L

God morgen indeed

E_L

The SC combo trial adds an extra arm, (D-Kd)
https://clinicaltrials.gov/ct2/history/NCT03412565?A=12&B=13&C=merged

gentogen

Thanks El. Og lidt apropos: WM cell lines treated with the ibrutinib + Dara combination, showed significantly more cell death through ADCC, CDC, ADCP and apoptosis relative to single‐agent Dara or ibrutinib. In summary, we are the first to report the in vitro and in vivo anti‐WM activity of Dara. Furthermore, we show a close connection between BCR and CD38 signalling, which can be co‐targeted with ibrutinib + Dara to induce marked WM cell death.(British Journal of Haematology 183(2) · August18

polle1

"Pop"

OHW

Fin kursudvikling

Legolas23

THX for link

StockBull

Ser ud til shorts er øget med 0.4% i.f.t September som var 3.27% 30 sept. mod nu 3.65% 31 okt.

Parasitism

Det passer vel også meget godt - var det ikke ca. 1 nov. at AB begyndte at ligge som største nettokøber mange af dagene?

Bulder

Despite the addition of a new arm, the sc combo trial is shortened down with almost a year. And at the same time the observation time frames are extended with a year. Any ideas how this fits together?

E_L

I can only think that recruitment is going much faster as expected? And it would almost imply this 4th arm is already recruiting?

Bulder

Yes, and the overall status is still active not recruiting. Which probably means that they've already got the pts they need for the new arm.

E_L

it would be nice if Genmab could next week update us on the timing for SC approval , it is so important

StockBull

Øv - ser ikke ud til der er købere nok til at bryde 1000kr idag og Fredag er normalt minus dag

StockBull

Håber sku Jan kommer med et lidt bedre end venter regnskab i næste uge så vi kan give kurs 1000 baghjul

JKY_VH

Dax er gået i minus og vi er tæt på frokost

sowise

https://ir.genmab.com/news-releases/news-release-details/genmab-present-jefferies-2018-london-healthcare-conference

peter12

Ang den artikel @EL linkede i formiddags https://twitter.com/NEJM/status/1060309673826574336 Er der nogen der ved om Dara skal godkendes til det ?