Genmab — November 2018
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To prove the anti-leukemic activity of daratumumab in AML in vivo https://ash.confex.com/ash/2018/webprogram/Paper113287.html
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Conclusions: CyBorD-DARA is a highly active, well tolerated induction therapy for NDMM patients undergoing ASCT. https://ash.confex.com/ash/2018/webprogram/Paper112375.html
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Conclusions:
CyBorD-DARA is a highly active, well tolerated induction therapy for NDMM patients undergoing ASCT. https://ash.confex.com/ash/2018/webprogram/Paper112375.html -
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Addition of tretinoin (ATRA) induced a ~4-fold increase of CD38 expression in AML blasts and to a lower extent in normal donor cells. In fact, combination of tretinoin and daratumumab led to an enhanced anti-leukemic activity in AML - Vi mangler i den grad in vivo data og burde vel have dem nu !
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