Genmab — Oktober 2018

JørgenVarnæs

ok - tak. så er der vist ingen grund til at sidde på stilke over wekenden

E_L

Huge New trial, D-RVd, 690 patients Ph III, SC,
https://clinicaltrials.gov/ct2/show/NCT03710603?term=daratumumab+OR+ofatumumab+OR+tisotumab&lupd_s=10%2F18%2F2018&rank=3

E_L

this was Griffin https://clinicaltrials.gov/ct2/show/NCT02874742?term=MMY2004&rank=2
and this one was announce in the summer https://clinicaltrials.gov/ct2/show/NCT03652064?term=Daratumumab+VELCADE+Lenalidomide+Dexamethasone&rank=2

E_L

so the differnence with the summer trial is transplant or not? (summer was also already SC)

E_L

this Ofatumumab RMS -autoinjector trial started recruiting https://clinicaltrials.gov/ct2/history/NCT03560739?A=1&B=2&C=merged

Bulder

Yes, the new one must be the continuation of Griffin in the transplant setting.

Bulder

But primary outcome still pfs and nor mrd, which is secondary. Pfs up to 9(!) years.

Bulder

nor=not

Bulder

But it does not rule out a filing for approval after Griffin-read-out. An approval can be given on the condition of a phase 3 study.

E_L

9 years??? wtf...
hadn't seen that yet...

E_L

good point. anyway , it points to a good read-out, doesn't it, otherwise you dont start 2 (big) trials so fast afterwards

Bulder

Primary completion May 2029! I'm sure they'll file.

Bulder

... after the phase 2.

E_L

sounds very comforting

E_L

the JNJ BCMA CD3 DuoBody is near primary completion date on Nov 1; they moved the final completion date to Oct 2019 ; 1 year earlier https://clinicaltrials.gov/ct2/history/NCT03145181?A=10&B=11&C=merged

Helge_LarsenPI-redaktør

Jeg har desværre en meget sørgelig meddelelse: Analytiker og redaktør for ØU og Nordic Biotech og tidligere flerårig flittig anonym skribent på de sociale aktiemedier Peter Aabo er sidste torsdag 43 år gammel afgået pludseligt ved døden pga en blodprop. Vi er mange her fra PI som har skrevet i samme tråde som ham og nydt godt af hans venlighed og kompetencer indenfor biotek - og pharmaindustrien. Mine tanker går til hans datter og til resten af den nære familie.

Helge_LarsenPI-redaktør

Bisættelsen fandt sted i eftermiddag. RIP Peter Aabo.

Solsen

Puha en mavepuster Helge - RIP Peter.

Sukkeralf

Ja meget trist - kondulerer

pauly

Det var da en rædsom ung alder at gå bort. Stadig en ung mand.