Genmab — Juli 2018
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Det er en meget lille indikation uden effektive behandlingsmuligheder.
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Jeg mener, at Novod for et par år siden fortalt en fantastisk historie om virkningen af Daratumumab hos en kvinde med sygdommen.
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"I
n addition to the 6 patients who achieved complete responses with daratumumab, 3 patients had very good partial responses, and 7 had partial responses. Only 2 patients did not achieve an objective response to treatment with daratumumab, Kaufman reported" -
"Response, including complete response, occurred as early as 1 month (or sooner) after the start of treatment. As an example of the activity observed in the study, Kaufman described a patient who had received 6 prior lines of therapy, including autologous stem-cell transplantation, and achieved a complete response within the first month after starting daratumumab infusions".
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Umiddelbart er der 4.500 nye patienter om året i USA med sygdommen. http://amyloidosis.org/facts/al/
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In the United States, AL amyloidosis is the most common type, with approximately 4,500 new cases diagnosed every year. It usually affects people from ages 50-80, although there are a few cases of people being diagnosed as early as their late 20s. About two-thirds of the patients are male." -
Hvis vi antager 20.000 WW til 1,5mill.kr, så bliver det 30mia kr. eller 4.5bn$, hvoraf 60% vel er maintenance, som så skal have behandling videre med Dara, så når vi vel op på cirka 6bn$, altså 6-dobbelt BB og royalties på ca. 1bn$, noget jeg regner forkert?
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En eventuel udmelding omkring Orphan designation skal vel komme fra Janssen?
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