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Genmab — Juni 2018

Planlagt Fastgjort Låst Flyttet Genmab
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  • StockBullS Offline
    StockBullS Offline
    StockBull
    wrote on sidst redigeret af
    #438

    Link Preview Image
    Genmab, Johnson and Johnson’s Trial of Darzalex in Solid Tumors is Cancelled – Patient Worthy

    favicon

    (patientworthy.com)

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    • StockBullS Offline
      StockBullS Offline
      StockBull
      wrote on sidst redigeret af
      #439

      Secondly, and perhaps more worryingly, the committee’s report stated that there was a marked increase in “mortality-related events.” This suggests that not only was Darzalex not effective in treating the cancer, but it was actually potentially causing harm to the patients.

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      • StockBullS Offline
        StockBullS Offline
        StockBull
        wrote on sidst redigeret af
        #440

        Det kan vel ligesågodt være de andre produkter som har været for giftige og ikke Darzalex

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        • StockBullS Offline
          StockBullS Offline
          StockBull
          wrote on sidst redigeret af
          #441

          Det er ligefør man tænker at forfatteret er bestilt af AQR til at skrive negativt og Darzalex

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          • StockBullS Offline
            StockBullS Offline
            StockBull
            wrote on sidst redigeret af
            #442

            forfatteren

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            • Helge_LarsenPI-redaktørH Offline
              Helge_LarsenPI-redaktørH Offline
              Helge_LarsenPI-redaktør
              wrote on sidst redigeret af
              #443

              Stockbull...De spekulationer har også været nævnt andre steder lige efter meddelelsen om stoppet kom.

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              • StockBullS Offline
                StockBullS Offline
                StockBull
                wrote on sidst redigeret af
                #444

                Ja det så jeg godt, men de bliver tilsyneladende ved med at puste til bålet selv og der har været tid nok til at undersøge sagerne lidt grundigere

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                • SolsenS Offline
                  SolsenS Offline
                  Solsen
                  wrote on sidst redigeret af
                  #445

                  Hvad gør man ikke for penge 😉

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                  • SolsenS Offline
                    SolsenS Offline
                    Solsen
                    wrote on sidst redigeret af
                    #446

                    Men faktuelt ser det jo nok ud til at være rigtigt, at dara ikke i kombination med tecentriq gør noget godt. Men langt over 10.000 pts oplever ikke problemer i andre kombinationer i bl.a. MM.

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                    • Legolas23L Offline
                      Legolas23L Offline
                      Legolas23
                      wrote on sidst redigeret af
                      #447

                      Også kan man tænke over hvorfor CHMP lægger begrænsninger på brugen af Keytruda og Tecentriq i hver deres kombinationer. Mon ikke trickeren der trækker i den gale retning ligeså godt være i Tecentriq. Det gør kun BMS-studierne med Dara mere spændende 😉

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                      • SolsenS Offline
                        SolsenS Offline
                        Solsen
                        wrote on sidst redigeret af
                        #448

                        Selvfølge en mulighed ja. Men det ligner no go med tecentriq plus dara.

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                        • G Offline
                          G Offline
                          gentogen
                          wrote on sidst redigeret af
                          #449

                          Alcyone: First randomized phase 3 study to demonstrate MRD negativity
                          using NGS in NDMM patients ≥75 years of age

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                          • G Offline
                            G Offline
                            gentogen
                            wrote on sidst redigeret af
                            #450

                            404 Not Found

                            favicon

                            (files.shareholder.com)

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                            • M Offline
                              M Offline
                              Mcjean
                              wrote on sidst redigeret af
                              #451

                              Se table 3 Bummelum nogen der er i tvivl om Dara's effekt?

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                              • M Offline
                                M Offline
                                Mcjean
                                wrote on sidst redigeret af
                                #452

                                Det eneste minus jeg kan se er 20-30% flere infektioner med Dara og måske derfor de meget svage står af eller?

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                                • E Offline
                                  E Offline
                                  E_L
                                  wrote on sidst redigeret af
                                  #453

                                  http://www.multiplemyelomahub.com/medical-information/philippe-moreau-asco-2018-critical-trials-in-mm-that-could-change-clinical-practice Philippe Moreau | ASCO 2018 | Critical trials in MM that could change clinical practice

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                                  • E Offline
                                    E Offline
                                    E_L
                                    wrote on sidst redigeret af
                                    #454

                                    that may be better with SC Mcjean, better safety profile. Anyone have any of the other posters?

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                                    • E Offline
                                      E Offline
                                      E_L
                                      wrote on sidst redigeret af
                                      #455

                                      https://twitter.com/search?f=tweets&vertical=default&q=genmab OR daratumumab OR darzalex OR ofatumumab&src=savs

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                                      • E Offline
                                        E Offline
                                        E_L
                                        wrote on sidst redigeret af
                                        #456

                                        IRR 40-50% in IV, 16% in SC

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                                        • E Offline
                                          E Offline
                                          E_L
                                          wrote on sidst redigeret af
                                          #457

                                          ORR 31% IV, 52% SC

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