Genmab — Maj 2018
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Integrative analysis reveals CD38 as a therapeutic target for plasma cell-rich pre-disease and established rheumatoid arthritis and systemic lupus erythematosus.
Most importantly, our data show for the first time that daratumumab effectively depletes plasma cells/plasmablasts in PBMC from patients with SLE and RA in a dose-dependent manner ex vivo.
http://www.ncbi.nlm.nih.gov/pubmed/29720240 -
Daratumumab, lenalidomide, and dexamethasone in East Asian patients with relapsed or refractory multiple myeloma: subgroup analyses of the phase 3 POLLUX study.
The efficacy and safety profiles of targeted anticancer therapies in East Asian patients may differ from those of the overall study populations in clinical trials14,15. To understand the impact of DRd vs. Rd in the East Asian patient population, we performed subanalyses of POLLUX data to evaluate the efficacy and safety of DRd vs. Rd in -
...East Asian (Japanese, Korean, and Taiwanese) patients as well as in only Japanese patients.
Reslutatet var enslydende med POLLUX generelt.
East Asian (Japanese, Korean, and Taiwanese) patients as well as in only Japanese patients.
Reslutatet var enslydende med POLLUX generelt.
East Asian (Japanese, Korean, and Taiwanese) patients as well as in only Japanese patients.
Reslutatet var enslydende med POLLUX generelt.
http://www.ncbi.nlm.nih.gov/pubmed/29712896 -
Immunomodulatory effects of CD38-targeting antibodies. God indblik i den avancerede molekylære mekanisme + nye muligheder.
https://sci-hub.hk/10.1016/j.imlet.2018.04.005 -
Durable treatment response of relapsing CNS plasmacytoma using intrathecal chemotherapy, radiotherapy, and Daratumumab
Although the therapy of CNS EMM is dif- ficult, the present case illustrates that a durable response (19 months) can be achieved by using systemic daratumumab therapy, IT chemotherapy, and craniospinal radiotherapy, which compares favorably to the reported literature.https://sci-hub.hk/10.1002/ccr3.1451 -
Responses to daratumumab in AL (immunoglobulin light chain) amyloidosis have also been reported.5 In our patient with POEMS syndrome, the remarkable response to daratumumab and lenalidomide suggests that this combination is a promising nontoxic alternative to ASCT that warrants exploration in POEMS syndrome.
https://www.mayoclinicproceedings.org/article/S0025-6196(18)30098-3/fulltext -
Tusinde tak for masser af spændende læsestof.
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Til jer der ikke har set linket til full-text artikler før, gentages det...https://sci-hub.hk/..indtast DOI nummer (bedst)
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...mth. full-text artikler adskillige domæner tilgængelige, hvis ét af dem ikke fungerer..se her https://en.wikipedia.org/wiki/Sci-Hub
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Den amerikanske medicinalindustri bereder sig på Trump-tale
Den amerikanske præsident, Donald Trump, ventes senere på ugen at afsløre mere eller mindre konkrete planer for, hvordan man vil komme de opskruede medicinpriser i landet til livs.
(medwatch.dk)
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