Genmab — April 2018
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Nej, ikke så potentielt toksisk og dyrt som car-t, men det er typisk noget som hospitaler selv skal 'samle': men køber isotopen og en særlig modificeret dara. Det er som sådan heller ikke et nyt koncept som car-t. Det er meget myndigheder
, der har åbnet for muligheden, men der er stærkt overvåget. -
Tak JDam
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Selv tak, GeorgeBest. Nu skal man jo aldrig sige aldrig - jeg ser ikke brug af actinium komme ret højt op i linjerne til denne behandling. De andre kan ikke undværes. Actinium og andre alpha emittere har også god effekt i andre sygdomme og der er det også svært fx. PCa.
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Tallet for Symphony Health Solution er 108,7 mio US dollars. En stigning fra februar (90,2) på 20,5 %.
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God morgen.
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Tisotumab Vedotin mention in the Seattle Genetics Q1 2018 Results http://investor.seattlegenetics.com/phoenix.zhtml?c=124860&p=irol-newsArticle&ID=2345077
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" Tisotumab Vedotin (TV) Program Activities
Planned Pivotal Trial Initiation: Seattle Genetics and Genmab plan to advance TV into a pivotal phase 2 trial for recurrent or metastatic cervical cancer that relapses or progresses after standard of care treatment for cervical cancer. The single-arm trial is designed to enroll approximately 100 women and could potentially support registration under the FDA’s accelerated approval regulations.
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The trial is expected to begin in the first half of 2018".
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"Expanding Clinical Development Program: Seattle Genetics and Genmab plan to initiate in 2018 a phase 2 trial of TV as part of a combination regimen in women with first-line metastatic cervical cancer. In addition, a phase 2 trial is expected to begin in 2018 to evaluate TV monotherapy in a range of other solid tumors"
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Thanks E L
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also the Earnings Call Transcript for those interested - https://seekingalpha.com/article/4166737-seattle-genetics-sgen-q1-2018-results-earnings-call-transcript?part=single - doesnt say much more, except that they work closely with Genmab, have visited them and that they think they will accrue the trials very rapidly and then get data 'very fast'.
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Der forskes en del i målrettet actinium 225 terapi - ikke mindst i prostata cancer. https://www.sciencedaily.com/releases/2017/10/171003111051.htm Men også i MM kører der kliniske forsøg. F.eks. Lintuzumab (cd33) koblet med Ac225. https://www.clinicaltrials.gov/ct2/show/NCT02998047?term=actinium&rank=2
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